PDB entry 5wfm
View 5wfm on RCSB PDB site
Description: Crystal structure of the influenza virus PA endonuclease (E119D mutant) in complex with inhibitor 10e (SRI-30024)
Class: hydrolase/hydrolase inhibitor
Keywords: Virus, Nuclease, Transcription, Cap-snatching, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2017-07-12, released
2018-01-03
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-12-11, with a file datestamp of
2019-12-06.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Polymerase acidic protein
Species: Influenza A virus [TaxId:641501]
Gene: PA
Database cross-references and differences (RAF-indexed):
- Uniprot C3W5S0 (20-69)
- expression tag (17-19)
- linker (70-72)
- Uniprot C3W5S0 (73-End)
- engineered mutation (119)
Domains in SCOPe 2.08: d5wfma1, d5wfma2 - Heterogens: KU5, MN, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5wfmA (A:)
mgsshhhhhhssglvprgshmedfvrqcfnpmivelaekamkeygedpkietnkfaaict
hlevcfmysdggskhrfeiiegrdrimawtvvnsicnttgvekpkflpdlydykenrfid
igvtrrevhiyylekankiksekthihifsftgeematkadytldeesrariktrlftir
qemasrslwdsfrqser
Sequence, based on observed residues (ATOM records): (download)
>5wfmA (A:)
gshmedfvrqcfnpmivelaekamkeygedpkietnkfaaicthlevcfmysdggskhrf
eiiegrdrimawtvvnsicnttgvekpkflpdlydykenrfidigvtrrevhiyylekan
kiksekthihifsftgeematkadytldeesrariktrlftirqemasrslwdsfrqse