PDB entry 5wdy
View 5wdy on RCSB PDB site
Description: Crystal structure of WNK1 in complex with 1-cyclohexyl-N-({6-fluoro-1-[2-(3-methoxyphenyl)pyridin-4-yl]-1H-indol-3-yl}methyl)methanamine (compound 6)
Class: transferase
Keywords: kinase, inhibitor, TRANSFERASE
Deposited on
2017-07-06, released
2017-08-16
The last revision prior to the SCOPe 2.06 freeze date was dated
2017-08-16, with a file datestamp of
2017-08-11.
Experiment type: XRAY
Resolution: 2.46 Å
R-factor: N/A
AEROSPACI score: 0.21
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Serine/threonine-protein kinase WNK1
Species: Homo sapiens [TaxId:9606]
Gene: WNK1, HSN2, KDP, KIAA0344, PRKWNK1
Database cross-references and differences (RAF-indexed):
- Uniprot Q9H4A3
- engineered mutation (191-193)
Domains in SCOPe 2.06: d5wdya_ - Chain 'B':
Compound: Serine/threonine-protein kinase WNK1
Species: Homo sapiens [TaxId:9606]
Gene: WNK1, HSN2, KDP, KIAA0344, PRKWNK1
Database cross-references and differences (RAF-indexed):
- Uniprot Q9H4A3 (1-End)
- engineered mutation (191-193)
Domains in SCOPe 2.06: d5wdyb_ - Heterogens: A6S, ANP, MN, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5wdyA (A:)
geletkavgmsndgrflkfdieigrgsfktvykgldtettvevawcelqdrkltkserqr
fkeeaemlkglqhpnivrfydswestvkgkkcivlvtelmtsgtlktylkrfkvmkikvl
rswcrqilkglqflhtrtppiihrdlkcdnifitgptgsvkigdlglatlkradfaksvi
gtpefmapemyaaaydesvdvyafgmcmlematseypysecqnaaqiyrrvtsgvkpasf
dkvaipevkeiiegcirqnkderysikdllnhaffqeet
Sequence, based on observed residues (ATOM records): (download)
>5wdyA (A:)
etkavgmsndgrflkfdieigrgsfktvykgldtettvevawcelqdrkltkserqrfke
eaemlkglqhpnivrfydswestcivlvtelmtsgtlktylkrfkvmkikvlrswcrqil
kglqflhtrtppiihrdlkcdnifitgptgsvkigdlglatlkrapefmapemyaaayde
svdvyafgmcmlematseypysecqnaaqiyrrvtsgvkpasfdkvaipevkeiiegcir
qnkderysikdllnhaffqe
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5wdyB (B:)
geletkavgmsndgrflkfdieigrgsfktvykgldtettvevawcelqdrkltkserqr
fkeeaemlkglqhpnivrfydswestvkgkkcivlvtelmtsgtlktylkrfkvmkikvl
rswcrqilkglqflhtrtppiihrdlkcdnifitgptgsvkigdlglatlkradfaksvi
gtpefmapemyaaaydesvdvyafgmcmlematseypysecqnaaqiyrrvtsgvkpasf
dkvaipevkeiiegcirqnkderysikdllnhaffqeet
Sequence, based on observed residues (ATOM records): (download)
>5wdyB (B:)
eletkavgmsndgrflkfdieigrgsfktvykgldtettvevawcelqltkserqrfkee
aemlkglqhpnivrfydswestvkgkkcivlvtelmtsgtlktylkrfkvmkikvlrswc
rqilkglqflhtrtppiihrdlkcdnifitgptgsvkigdlglatlkrtpefmapemyaa
aydesvdvyafgmcmlematseypysecqnaaqiyrrvtsgsfdkvaipevkeiiegcir
qnkderysikdllnhaffq