PDB entry 5w73

View 5w73 on RCSB PDB site
Description: Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 9f (SRI-29835)
Class: hydrolase/hydrolase inhibitor
Keywords: Virus, Nuclease, Transcription, Cap-snatching, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-06-19, released 2018-01-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Polymerase acidic protein
    Species: Influenza A virus [TaxId:641501]
    Gene: PA
    Database cross-references and differences (RAF-indexed):
    • Uniprot C3W5S0 (20-69)
      • expression tag (17-19)
      • linker (70-72)
    • Uniprot C3W5S0 (73-End)
    Domains in SCOPe 2.08: d5w73a1, d5w73a2
  • Heterogens: MN, SO4, GY9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5w73A (A:)
mgsshhhhhhssglvprgshmedfvrqcfnpmivelaekamkeygedpkietnkfaaict
hlevcfmysdggskhrfeiiegrdrimawtvvnsicnttgvekpkflpdlydykenrfie
igvtrrevhiyylekankiksekthihifsftgeematkadytldeesrariktrlftir
qemasrslwdsfrqser

    Sequence, based on observed residues (ATOM records): (download) 
    >5w73A (A:)
gshmedfvrqcfnpmivelaekamkeygedpkietnkfaaicthlevcfmysdggskhrf
eiiegrdrimawtvvnsicnttgvekpkflpdlydykenrfieigvtrrevhiyylekan
kiksekthihifsftgeematkadytldeesrariktrlftirqemasrslwdsfrqse