PDB entry 5w59

View 5w59 on RCSB PDB site
Description: Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1c
Class: cytokine
Keywords: Growth factor, Growth Factor Receptor, ligand-receptor complex, CYTOKINE
Deposited on 2017-06-14, released 2017-08-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor 9
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF9
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31371
      • engineered mutation (161)
    Domains in SCOPe 2.07: d5w59a_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • conflict (45)
      • conflict (112)
    Domains in SCOPe 2.07: d5w59b1, d5w59b2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5w59A (A:)
mdhlgqseagglprgpavtdldhlkgilrrrqlycrtgfhleifpngtiqgtrkdhsrfg
ilefisiavglvsirgvdsglylgmnekgelygsekltqecvfreqfeenwyntyssnly
khvdtgrryyvalnkdgtpregtrtkrhqkfthflprpvdpakvpelykdaasqs

    Sequence, based on observed residues (ATOM records): (download) 
    >5w59A (A:)
kgilrrrqlycrtgfhleifpngtiqgtrkdhsrfgilefisiavglvsirgvdsglylg
mnekgelygsekltqecvfreqfeenwyntyssnlykhvdtgrryyvalnkdgtpregtr
tkrhqkfthflprpvdpakvpelykd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5w59B (B:)
madntkpnrmpvapywtspekmekklhavpaaktvkfkcpssgtpqptlrwlkngkefkp
dhriggykvryatwsiimdsvvpsdkgnytciveneygsinhtyqldvversrhrpilqa
glpanktvalgsnvefmckvysdpqphiqwlkhievngskigpdnlpyvqilktagvntt
dkemevlhlrnvsfedageytclagnsiglshhsawltvlealeer

    Sequence, based on observed residues (ATOM records): (download) 
    >5w59B (B:)
nrmpvapywtspekmekklhavpaaktvkfkcpssgtpqptlrwlkngkefkpdhriggy
kvryatwsiimdsvvpsdkgnytciveneygsinhtyqldvversrhrpilqaglpankt
valgsnvefmckvysdpqphiqwlkhievngslpyvqilktagvnttdkemevlhlrnvs
fedageytclagnsiglshhsawltvle