PDB entry 5vpy

View 5vpy on RCSB PDB site
Description: Crystal structure of human KRAS G12A mutant in complex with GppNHp
Class: hydrolase
Keywords: Oncogenic mutant, HYDROLASE
Deposited on 2017-05-06, released 2017-12-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-12-06, with a file datestamp of 2017-12-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-169)
      • expression tag (0)
      • engineered mutation (12)
      • engineered mutation (118)
    Domains in SCOPe 2.06: d5vpya1, d5vpya2
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-169)
      • expression tag (0)
      • engineered mutation (12)
      • engineered mutation (118)
    Domains in SCOPe 2.06: d5vpyb1, d5vpyb2
  • Heterogens: MG, 9GM, PG4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5vpyA (A:)
hmteyklvvvgaagvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >5vpyA (A:)
hmteyklvvvgaagvgksaltiqliqnhfvdeyddsyrkqvvidgetclldildtdqymr
tgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlpsrtvdtkqaqdl
arsygipfietsaktrqgvddafytlvreirkhkek

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5vpyB (B:)
hmteyklvvvgaagvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >5vpyB (B:)
hmteyklvvvgaagvgksaltiqliqnhfvdeyddsyrkqvvidgetclldildtdqymr
tgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlpsrtvdtkqaqdl
arsygipfietsaktrqgvddafytlvreirkhkek