PDB entry 5v7j

View 5v7j on RCSB PDB site
Description: Crystal Structure at 3.7 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Four Glycans (N197, N276, N362, and N462) removed in Complex with Neutralizing Antibodies 3H+109L and 35O22.
Class: viral protein/immune system
Keywords: HIV-1, Envelope, Antibody, Virus, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2017-03-20, released 2017-06-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-09.
Experiment type: XRAY
Resolution: 2.91 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6 (0-152)
      • engineered mutation (93)
  • Chain 'D':
    Compound: Antibody 35O22 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5V7J (0-239)
  • Chain 'E':
    Compound: Antibody 35O22 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5V7J
    Domains in SCOPe 2.08: d5v7je1, d5v7je2
  • Chain 'G':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6 (0-End)
      • engineered mutation (167)
      • engineered mutation (246)
      • engineered mutation (299)
      • engineered mutation (332)
      • engineered mutation (430)
      • engineered mutation (467)
  • Chain 'H':
    Compound: Antibody 3H+109L Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5V7J (0-End)
    Domains in SCOPe 2.08: d5v7jh1, d5v7jh2
  • Chain 'L':
    Compound: Antibody 3H+109L Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5V7J
    Domains in SCOPe 2.08: d5v7jl1, d5v7jl2
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'B':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5v7jE (E:)
qsvltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapgi
sprfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkvsvlgqskanpsvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >5v7jE (E:)
svltqsasvsgslgqsvtisctgpnsvccshksiswyqwppgraptliiyednerapgis
prfsgyksywsayltisdlrpedettyyccsythnsgcvfgtgtkvsvlgqskanpsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5v7jH (H:)
qvqlqesgpglvkpsetlsltctvsggsisnyywswirqspgkglewigyisdsestnyn
pslksrviisvdtsknqlslklnsvtaadsaiyycaraqqgkriygmvsfgeffyyyymd
vwgkgttvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscd

    Sequence, based on observed residues (ATOM records): (download) 
    >5v7jH (H:)
qvqlqesgpglvkpsetlsltctvsggsisnyywswirqspgkglewigyisdsestnyn
pslksrviisvdtsknqlslklnsvtaadsaiyycaraqqgkriygmvsfgeffyyyymd
vwgkgttvtvssastkgpsvfplapssstsggtaalgclvkdyfpepvtvswnsgaltsg
vhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5v7jL (L:)
gsvtsyvrplsvalgetasiscgrqalgsravqwyqhrpgqapilliynnqdrpsgiper
fsgtpdinfgtratltisgveagdeadyychmwdsrsgfswsfggatrltvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshksyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >5v7jL (L:)
syvrplsvalgetasiscgrqalgsravqwyqhrpgqapilliynnqdrpsgiperfsgt
pdinfgtratltisgveagdeadyychmwdsrsgfswsfggatrltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshksyscqvthegstvektvapt