PDB entry 5v03

View 5v03 on RCSB PDB site
Description: A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
Class: TRANSPORT PROTEIN/Metal Binding protein
Keywords: calcium-activated ion channels, activator, calmodulin, TRANSPORT PROTEIN-Metal Binding protein complex
Deposited on 2017-02-28, released 2018-03-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-03-07, with a file datestamp of 2018-03-02.
Experiment type: XRAY
Resolution: 1.58 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Small conductance calcium-activated potassium channel protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KCNN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H2S1 (2-93)
      • expression tag (1)
      • expression tag (94-95)
    Domains in SCOPe 2.07: d5v03b1, d5v03b2, d5v03b3
  • Chain 'R':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5v03r_
  • Heterogens: SO4, 658, CA, HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5v03B (B:)
mgrkleltkaekhvhnfmmdtqltkrvknaaanvlretwliykntklvkkidhakvrkhq
rkflqaihqlrsvkmeqrklndqantlvdlaktqlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5v03B (B:)
grkleltkadtqltkrvknaaanvlretwliykntklvkkidhakvrkhqrkflqaihql
rsvkmeqrklndqantlvdlaktqle

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >5v03R (R:)
madqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadg
ngtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltde
evdemireadidgdgqvnyeefvqmmtak

    Sequence, based on observed residues (ATOM records): (download) 
    >5v03R (R:)
qlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngt
idfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevd
emireadidgdgqvnyeefvqmmta