PDB entry 5uv5

View 5uv5 on RCSB PDB site
Description: Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase
Class: transferase/transferase inhibitor
Keywords: REVERSE TRANSCRIPTASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2017-02-19, released 2017-08-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-04, with a file datestamp of 2017-09-29.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) [TaxId:11678]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366
      • engineered mutation (281)
    Domains in SCOPe 2.07: d5uv5a1, d5uv5a2
  • Chain 'B':
    Compound: p51 RT
    Species: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) [TaxId:11678]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366 (1-End)
      • expression tag (0)
      • engineered mutation (280)
    Domains in SCOPe 2.07: d5uv5b1, d5uv5b2
  • Chain 'C':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) [TaxId:11678]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366
      • engineered mutation (281)
    Domains in SCOPe 2.07: d5uv5c1, d5uv5c2
  • Chain 'D':
    Compound: p51 RT
    Species: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) [TaxId:11678]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366
      • engineered mutation (280)
    Domains in SCOPe 2.07: d5uv5d_
  • Heterogens: MN, Y55

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5uv5A (A:)
    mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
    pvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsv
    pldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdi
    viyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdk
    wtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkaltevipltee
    aelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmr
    gahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvn
    tpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqkte
    lqaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpa
    hkgiggneqvdklvsag
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uv5A (A:)
    pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfar
    klvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkytafti
    pgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymddlyvgsdleigqhr
    tkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqk
    lvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyy
    dpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittes
    iviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaet
    fyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiylalqdsglevnivtds
    qyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvs
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5uv5B (B:)
    gpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntp
    vfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvp
    ldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiv
    iyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkw
    tvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteea
    elelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrg
    ahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvnt
    pplvklwyq
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uv5B (B:)
    gpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntp
    vfaikkkdstkwrklvdfrelnkrtqdfwphpaglkkkksvtvldvgdayfsvpldedfr
    kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymd
    dlyvgsdleigqhrtkieelrqhllrwggyelhpdkwtvqpivlpekdswtvndiqklvg
    klnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydps
    kdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesivi
    wgktpkfklpiqketwetwwteywqatwipewefvntppl
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5uv5C (C:)
    mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
    pvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsv
    pldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdi
    viyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdk
    wtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkaltevipltee
    aelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmr
    gahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvn
    tpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqkte
    lqaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpa
    hkgiggneqvdklvsag
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uv5C (C:)
    spietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfa
    ikkkdstwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplded
    frkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqy
    mddlyvgsdleigqhrtkieelrqhllrwglttpdkhqkeppflwmgyelhpdkwtvqpi
    vlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelela
    enreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaahtndvkql
    teavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
    lekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiylalqd
    sglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqv
    dklvsa
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5uv5D (D:)
    gpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntp
    vfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvp
    ldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiv
    iyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkw
    tvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteea
    elelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrg
    ahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvnt
    pplvklwyq
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uv5D (D:)
    tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaiktk
    wrklvdfrelnkrtqdflgiphpaglkkkksvtvldvgdayfsvpldedfrkytaftips
    innetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymddlyvgsdle
    igqhrtkieelrqhllrwgltelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiy
    pgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqk
    qgqgqwtyqiyqepfknlktgkyarmrtndvkqlteavqkittesiviwgktpkfklpiq
    ketwetwwteywqatwipewefvntpplvklwy