PDB entry 5uqx

View 5uqx on RCSB PDB site
Description: USP7 in complex with GNE6776 (6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl-[3,3'-bipyridine]-6-carboxamide)
Class: hydrolase/hydrolase inhibitor
Keywords: HAUSP, USP7, SBDD, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-02-08, released 2017-10-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.23 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin carboxyl-terminal hydrolase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: USP7, HAUSP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5uqxa_
  • Chain 'B':
    Compound: Ubiquitin carboxyl-terminal hydrolase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: USP7, HAUSP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5uqxb_
  • Heterogens: 8JP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uqxA (A:)
mgsshhhhhhssglvprgshmkkhtgyvglknqgatcymnsllqtlfftnqlrkavymmp
tegddssksvplalqrvfyelqhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldn
venkmkgtcvegtipklfrgkmvsyiqckevdyrsdrredyydiqlsikgkknifesfvd
yvaveqldgdnkydagehglqeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfe
fpeqlpldeflqktdpkdpanyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvs
rctkeeaiehnygghdddlsvrhctnaymlvyiresklsevlqavtdhdipqqlverlqe
ekrieaqkr

    Sequence, based on observed residues (ATOM records): (download) 
    >5uqxA (A:)
khtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfyelq
hsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfrgkm
vsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehglqe
aekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdpany
ilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddlsvr
hctnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaqk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uqxB (B:)
mgsshhhhhhssglvprgshmkkhtgyvglknqgatcymnsllqtlfftnqlrkavymmp
tegddssksvplalqrvfyelqhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldn
venkmkgtcvegtipklfrgkmvsyiqckevdyrsdrredyydiqlsikgkknifesfvd
yvaveqldgdnkydagehglqeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfe
fpeqlpldeflqktdpkdpanyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvs
rctkeeaiehnygghdddlsvrhctnaymlvyiresklsevlqavtdhdipqqlverlqe
ekrieaqkr

    Sequence, based on observed residues (ATOM records): (download) 
    >5uqxB (B:)
kkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfyel
qhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfrgk
mvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehglq
eaekgvkfltlppvlhlqlmrfmikindrfefpeqlpldeflqktdpkdpanyilhavlv
hsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghctnaymlvyiresk
lsevlqavtdhdipqqlverlqeekrieaqkr