PDB entry 5uoy

View 5uoy on RCSB PDB site
Description: Crystal structure of human PDE1B catalytic domain in complex with inhibitor 16j (6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one)
Class: hydrolase/hydrolase inhibitor
Keywords: hydrolase, hydrolase inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-02-01, released 2017-04-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-05-10, with a file datestamp of 2017-05-05.
Experiment type: XRAY
Resolution: 1.82 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE1B, PDE1B1, PDES1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5uoya_
  • Heterogens: ZN, MG, 8HM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5uoyA (A:)
    vgptystavlnclknldlwcfdvfslnqaaddhalrtivfelltrhnlisrfkiptvflm
    sfldaletgygkyknpyhnqihaadvtqtvhcfllrtgmvhclseiellaiifaaaihdy
    ehtgttnsfhiqtksecaivyndrsvlenhhissvfrlmqddemnifinltkdefvelra
    lviemvlatdmschfqqvktmktalqqleridkpkalslllhaadishptkqwlvhsrwt
    kalmeeffrqgdkeaelglpfsplcdrtstlvaqsqigfidfiveptfsvltdvaeksvq
    pladedsksknqpsfqwrqpsldvevgdpnpdvvsfrstwvkriqenkqkwkeraasgit
    n
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uoyA (A:)
    ystavlnclknldlwcfdvfslnqaaddhalrtivfelltrhnlisrfkiptvflmsfld
    aletgygkyknpyhnqihaadvtqtvhcfllrtgmvhclseiellaiifaaaihdyehtg
    ttnsfhiqtksecaivyndrsvlenhhissvfrlmqddemnifinltkdefvelralvie
    mvlatdmschfqqvktmktalqqleridkpkalslllhaadishptkqwlvhsrwtkalm
    eeffrqgdkeaelglpfsplcdrtstlvaqsqigfidfiveptfsvltdvaeksvpdvvs
    frstwvkriqenkqkwkeraa