PDB entry 5ukm

View 5ukm on RCSB PDB site
Description: bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as)
Class: Transferase/Signaling Protein
Keywords: kinase, inhibitor complex, Transferase-Signaling Protein complex
Deposited on 2017-01-23, released 2017-04-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 3.03 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Bos taurus [TaxId:9913]
    Gene: GRK2, ADRBK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ukma1, d5ukma2, d5ukma3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ukmb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ukmg_
  • Heterogens: T0E, MG, CMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ukmA (A:)
madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
qklgyllfrdfclkhleeakplvefyeeikkyekleteeerlvcsreifdtyimkellac
shpfsksaiehvqghlvkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
ktknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
ltmeeiqsveetqikerkclllkirggkqfvlqcdsdpelvqwkkelrdayreaqqlvqr
vpkmknkprapvvelskvpliqrgsanglhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5ukmA (A:)
killpepsirsvmqkyledrgevtfekifsqklgyllfrdfclkhleeakplvefyeeik
kyekleteeerlvcsreifdtyimkellacshpfsksaiehvqghlvkkqvppdlfqpyi
eeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcrk
adtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsfi
ldlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehgh
vrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghsp
frqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevkes
pffrsldwqmvflqkyppplipprgevnaadafdiklldsdqelyrnfpltiserwqqev
aetvfdtinaetdrlearkktknkqlgheedyalgkdcimhgymskmwqrryfylfpnrl
ewrgegeapqslltmeeiqsveetqikerkclllkirggkqfvlqcdsdpelvqwkkelr
dayreaqqlvqrvpkmknkpr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ukmB (B:)
mhhhhhhgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrt
lrghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgn
yvacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwd
ietgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdin
aicffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyd
dfncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >5ukmB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5ukmG (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records): (download) 
    >5ukmG (G:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkff