PDB entry 5ukm

View 5ukm on RCSB PDB site
Description: bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as)
Class: Transferase/Signaling Protein
Keywords: kinase, inhibitor complex, Transferase-Signaling Protein complex
Deposited on 2017-01-23, released 2017-04-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-04-12, with a file datestamp of 2017-04-07.
Experiment type: XRAY
Resolution: 3.03 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Bos taurus [TaxId:9913]
    Gene: GRK2, ADRBK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ukma1, d5ukma2, d5ukma3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ukmb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ukmg_
  • Heterogens: T0E, MG, CMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5ukmA (A:)
    madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
    qklgyllfrdfclkhleeakplvefyeeikkyekleteeerlvcsreifdtyimkellac
    shpfsksaiehvqghlvkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
    elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
    imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
    iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
    vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
    lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
    dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
    ktknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
    ltmeeiqsveetqikerkclllkirggkqfvlqcdsdpelvqwkkelrdayreaqqlvqr
    vpkmknkprapvvelskvpliqrgsanglhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ukmA (A:)
    killpepsirsvmqkyledrgevtfekifsqklgyllfrdfclkhleeakplvefyeeik
    kyekleteeerlvcsreifdtyimkellacshpfsksaiehvqghlvkkqvppdlfqpyi
    eeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcrk
    adtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsfi
    ldlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehgh
    vrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghsp
    frqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevkes
    pffrsldwqmvflqkyppplipprgevnaadafdiklldsdqelyrnfpltiserwqqev
    aetvfdtinaetdrlearkktknkqlgheedyalgkdcimhgymskmwqrryfylfpnrl
    ewrgegeapqslltmeeiqsveetqikerkclllkirggkqfvlqcdsdpelvqwkkelr
    dayreaqqlvqrvpkmknkpr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5ukmB (B:)
    mhhhhhhgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrt
    lrghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgn
    yvacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwd
    ietgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdin
    aicffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyd
    dfncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ukmB (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
    ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
    atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
    adragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >5ukmG (G:)
    masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
    frekkffcail
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ukmG (G:)
    siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkff