PDB entry 5ukl

View 5ukl on RCSB PDB site
Description: Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd)
Class: transferase/transferase inhibitor
Keywords: kinase, inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2017-01-23, released 2017-04-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GRK2, ADRBK1, BARK, BARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25098 (Start-641)
      • engineered mutation (640)
    Domains in SCOPe 2.07: d5ukla1, d5ukla2, d5ukla3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5uklb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5uklg_
  • Heterogens: MG, SIX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5uklA (A:)
    kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeei
    kkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqpy
    ieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcr
    kadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsf
    ildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehg
    hvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghs
    pfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevke
    spffrsldwqmvflqkyppplipprgevnaadafdigsfdeedtkgiklldsdqelyrnf
    pltiserwqqevaetvfdtinaetdrlearkkaknkqlgheedyalgkdcimhgymskmg
    npfltqwqrryfylfpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggkq
    filqcdsdpelvqwkkelrdayreaqqlvqrvpkmknkprap
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uklA (A:)
    killpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeeik
    kyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqpyi
    eeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcrk
    adtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsfi
    ldlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehgh
    vrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghsp
    frqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevkes
    pffrsldwqmvflqkyppplipprgevnaadafdiklldsdqelyrnfpltiserwqqev
    aetvfdtinaetdrlearkkaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryf
    ylfpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelv
    qwkkelrdayreaqqlvqrvpkmknkprap
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5uklB (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
    ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
    atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
    adragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5uklG (G:)
    siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkff
    ca