PDB entry 5ukl

View 5ukl on RCSB PDB site
Description: Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd)
Class: transferase/transferase inhibitor
Keywords: kinase, inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2017-01-23, released 2017-04-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GRK2, ADRBK1, BARK, BARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25098 (Start-641)
      • engineered mutation (640)
    Domains in SCOPe 2.08: d5ukla1, d5ukla2, d5ukla3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uklb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uklg_
  • Heterogens: MG, SIX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uklA (A:)
kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeei
kkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqpy
ieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcr
kadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsf
ildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehg
hvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghs
pfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevke
spffrsldwqmvflqkyppplipprgevnaadafdigsfdeedtkgiklldsdqelyrnf
pltiserwqqevaetvfdtinaetdrlearkkaknkqlgheedyalgkdcimhgymskmg
npfltqwqrryfylfpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggkq
filqcdsdpelvqwkkelrdayreaqqlvqrvpkmknkprap

    Sequence, based on observed residues (ATOM records): (download) 
    >5uklA (A:)
killpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeeik
kyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqpyi
eeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcrk
adtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsfi
ldlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehgh
vrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghsp
frqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevkes
pffrsldwqmvflqkyppplipprgevnaadafdiklldsdqelyrnfpltiserwqqev
aetvfdtinaetdrlearkkaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryf
ylfpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelv
qwkkelrdayreaqqlvqrvpkmknkprap

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5uklB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5uklG (G:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkff
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