PDB entry 5ujt

View 5ujt on RCSB PDB site
Description: Crystal structure of human HLA-DQ8 in complex with insulin mimotope binding in register 3
Class: immune system
Keywords: insulin, type I diabetes, t cell, autoimmune disease, immune system
Deposited on 2017-01-18, released 2017-12-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-12-20, with a file datestamp of 2017-12-15.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class II antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQA1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5Y7C3 (Start-184)
      • conflict (75)
    Domains in SCOPe 2.06: d5ujta1, d5ujta2
  • Chain 'B':
    Compound: MHC class II HLA-DQ-beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ujtb1, d5ujtb2
  • Chain 'C':
    Compound: insulin mimotope
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5UJT (Start-15)
  • Chain 'D':
    Compound: MHC class II antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQA1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5Y7C3
      • conflict (75)
    Domains in SCOPe 2.06: d5ujtd1, d5ujtd2
  • Chain 'E':
    Compound: MHC class II HLA-DQ-beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ujte1, d5ujte2
  • Chain 'F':
    Compound: insulin mimotope
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5UJT
  • Chain 'G':
    Compound: MHC class II antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQA1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5Y7C3 (0-End)
      • conflict (75)
    Domains in SCOPe 2.06: d5ujtg1, d5ujtg2
  • Chain 'H':
    Compound: MHC class II HLA-DQ-beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ujth1, d5ujth2
  • Chain 'I':
    Compound: insulin mimotope
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5UJT
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ujtA (A:)
gedivadhvasygvnlyqsygpsgqyshefdgdeefyvdlerketvwqlplfrrfrrfdp
qfaltniavlkhnlncvikrsnstaatnevpevtvfskspvtlgqpntliclvdnifppv
vnitwlsnghsvtegvsetsflsksdhsffkisyltflpsddeiydckvehwgldepllk
hwepe

    Sequence, based on observed residues (ATOM records): (download) 
    >5ujtA (A:)
divadhvasygvnlyqsygpsgqyshefdgdeefyvdlerketvwqlplfrrfrrfdpqf
altniavlkhnlncvikrsnstaatnevpevtvfskspvtlgqpntliclvdnifppvvn
itwlsnghsvtegvsetsflsksdhsffkisyltflpsddeiydckvehwgldepllkhw
epe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ujtB (B:)
spedfvyqfkgmcyftngtervrlvtryiynreeyarfdsdvgvyravtplgppaaeywn
sqkevlertraeldtvcrhnyqlelrttlqrrveptvtispsrtealnhhnllvcsvtdf
ypaqikvrwfrndqeettgvvstplirngdwtfqilvmlemtpqrgdvytchvehpslqn
piivewraq

    Sequence, based on observed residues (ATOM records): (download) 
    >5ujtB (B:)
spedfvyqfkgmcyftngtervrlvtryiynreeyarfdsdvgvyravtplgppaaeywn
sqkevlertraeldtvcrhnyqlelrttlqrrveptvtispstealnhhnllvcsvtdfy
paqikvrwfrndqeettgvvstplirngdwtfqilvmlemtpqrgdvytchvehpslqnp
iivewraq

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5ujtD (D:)
gedivadhvasygvnlyqsygpsgqyshefdgdeefyvdlerketvwqlplfrrfrrfdp
qfaltniavlkhnlncvikrsnstaatnevpevtvfskspvtlgqpntliclvdnifppv
vnitwlsnghsvtegvsetsflsksdhsffkisyltflpsddeiydckvehwgldepllk
hwepe

    Sequence, based on observed residues (ATOM records): (download) 
    >5ujtD (D:)
edivadhvasygvnlyqsygpsgqyshefdgdeefyvdlerketvwqlplfrrfrrfdpq
faltniavlkhnlncvikrsnstaatnevpevtvfskspvtlgqpntliclvdnifppvv
nitwlsnghsvtegvsetsflsksdhsffkisyltflpsddeiydckvehwgldepllkh
w

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5ujtE (E:)
spedfvyqfkgmcyftngtervrlvtryiynreeyarfdsdvgvyravtplgppaaeywn
sqkevlertraeldtvcrhnyqlelrttlqrrveptvtispsrtealnhhnllvcsvtdf
ypaqikvrwfrndqeettgvvstplirngdwtfqilvmlemtpqrgdvytchvehpslqn
piivewraq

    Sequence, based on observed residues (ATOM records): (download) 
    >5ujtE (E:)
spedfvyqfkgmcyftngtervrlvtryiynreeyarfdsdvgvyravtplgppaaeywn
sqkevlertraeldtvcrhnyqlelrttlqrrveptvtispsrtealnhhnllvcsvtdf
ypaqikvrwfrndqeettgvvstplirngdwtfqilvmlemtpqrgdvytchvehpslqn
piivewra

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5ujtG (G:)
gedivadhvasygvnlyqsygpsgqyshefdgdeefyvdlerketvwqlplfrrfrrfdp
qfaltniavlkhnlncvikrsnstaatnevpevtvfskspvtlgqpntliclvdnifppv
vnitwlsnghsvtegvsetsflsksdhsffkisyltflpsddeiydckvehwgldepllk
hwepe

    Sequence, based on observed residues (ATOM records): (download) 
    >5ujtG (G:)
gedivadhvasygvnlyqsygpsgqyshefdgdeefyvdlerketvwqlplfrrfrrfdp
qfaltniavlkhnlncvikrsnstaatnevpevtvfskspvtlgqpntliclvdnifppv
vnitwlsnghsvtegvsetsflsksdhsffkisyltflpsddeiydckvehwgldepllk
hw

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5ujtH (H:)
spedfvyqfkgmcyftngtervrlvtryiynreeyarfdsdvgvyravtplgppaaeywn
sqkevlertraeldtvcrhnyqlelrttlqrrveptvtispsrtealnhhnllvcsvtdf
ypaqikvrwfrndqeettgvvstplirngdwtfqilvmlemtpqrgdvytchvehpslqn
piivewraq

    Sequence, based on observed residues (ATOM records): (download) 
    >5ujtH (H:)
spedfvyqfkgmcyftngtervrlvtryiynreeyarfdsdvgvyravtplgppaaeywn
sqkevlertraeldtvcrhnyqlelrttlqrrveptvtispnllvcsvtdfypaqikvrw
frndqeettgvvstplirngdwtfqilvmlemtpqrgdvytchvehpslqnpiivewra

  • Chain 'I':
    No sequence available.