PDB entry 5uip
View 5uip on RCSB PDB site
Description: structure of DHFR with bound DAP, p-ABG and NADP
Class: oxidoreductase
Keywords: DHFR, NADP, 2, 4 diaminopyridine, N-(4aminobenzoyl)-L-glutamate, OXIDOREDUCTASE
Deposited on
2017-01-14, released
2017-11-22
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-11-22, with a file datestamp of
2017-11-17.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: dihydrofolate reductase
Species: Escherichia coli [TaxId:562]
Gene: folA
Database cross-references and differences (RAF-indexed):
- Uniprot P0ABQ4 (1-158)
- expression tag (0)
- engineered mutation (151)
Domains in SCOPe 2.07: d5uipa1, d5uipa2 - Chain 'B':
Compound: dihydrofolate reductase
Species: Escherichia coli [TaxId:562]
Gene: folA
Database cross-references and differences (RAF-indexed):
- Uniprot P0ABQ4 (1-158)
- expression tag (0)
- engineered mutation (151)
Domains in SCOPe 2.07: d5uipb1, d5uipb2 - Heterogens: 8DM, LG3, NAP, NA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5uipA (A:)
gisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsysfeilerrgggg
Sequence, based on observed residues (ATOM records): (download)
>5uipA (A:)
gisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsysfeilerr
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5uipB (B:)
gisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsysfeilerrgggg
Sequence, based on observed residues (ATOM records): (download)
>5uipB (B:)
gisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsysfeilerr