PDB entry 5uio
View 5uio on RCSB PDB site
Description: structure of DHFR with bound DAP, p-ABG and NADP
Class: oxidoreductase
Keywords: DHFR, NADP, 2, 4 diaminopyridine, N-(4aminobenzoyl)-L-glutamate, OXIDOREDUCTASE
Deposited on
2017-01-14, released
2017-11-22
The last revision prior to the SCOPe 2.06 freeze date was dated
2017-11-22, with a file datestamp of
2017-11-17.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: dihydrofolate reductase
Species: Escherichia coli [TaxId:562]
Gene: folA
Database cross-references and differences (RAF-indexed):
- Uniprot P0ABQ4 (1-159)
- initiating methionine (0)
Domains in SCOPe 2.06: d5uioa_ - Chain 'B':
Compound: dihydrofolate reductase
Species: Escherichia coli [TaxId:562]
Gene: folA
Database cross-references and differences (RAF-indexed):
- Uniprot P0ABQ4 (1-159)
- initiating methionine (0)
Domains in SCOPe 2.06: d5uiob_ - Chain 'C':
Compound: dihydrofolate reductase
Species: Escherichia coli [TaxId:562]
Gene: folA
Database cross-references and differences (RAF-indexed):
- Uniprot P0ABQ4 (1-159)
- initiating methionine (0)
Domains in SCOPe 2.06: d5uioc_ - Chain 'D':
Compound: dihydrofolate reductase
Species: Escherichia coli [TaxId:562]
Gene: folA
Database cross-references and differences (RAF-indexed):
- Uniprot P0ABQ4 (1-159)
- initiating methionine (0)
Domains in SCOPe 2.06: d5uiod_ - Chain 'E':
Compound: dihydrofolate reductase
Species: Escherichia coli [TaxId:562]
Gene: folA
Database cross-references and differences (RAF-indexed):
- Uniprot P0ABQ4 (1-159)
- initiating methionine (0)
Domains in SCOPe 2.06: d5uioe_ - Heterogens: LG3, 8DM, NAP, BME, FMT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5uioA (A:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>5uioA (A:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerr
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5uioB (B:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>5uioB (B:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerr
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5uioC (C:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>5uioC (C:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerr
- Chain 'D':
Sequence, based on SEQRES records: (download)
>5uioD (D:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>5uioD (D:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerr
- Chain 'E':
Sequence, based on SEQRES records: (download)
>5uioE (E:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>5uioE (E:)
mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
egdthfpdyepddwesvfsefhdadaqnshsycfeilerr