PDB entry 5uio

View 5uio on RCSB PDB site
Description: structure of DHFR with bound DAP, p-ABG and NADP
Class: oxidoreductase
Keywords: DHFR, NADP, 2, 4 diaminopyridine, N-(4aminobenzoyl)-L-glutamate, OXIDOREDUCTASE
Deposited on 2017-01-14, released 2017-11-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Escherichia coli [TaxId:562]
    Gene: folA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0ABQ4 (1-159)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5uioa_
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: Escherichia coli [TaxId:562]
    Gene: folA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0ABQ4 (1-159)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5uiob_
  • Chain 'C':
    Compound: dihydrofolate reductase
    Species: Escherichia coli [TaxId:562]
    Gene: folA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0ABQ4 (1-159)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5uioc_
  • Chain 'D':
    Compound: dihydrofolate reductase
    Species: Escherichia coli [TaxId:562]
    Gene: folA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0ABQ4 (1-159)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5uiod_
  • Chain 'E':
    Compound: dihydrofolate reductase
    Species: Escherichia coli [TaxId:562]
    Gene: folA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0ABQ4 (1-159)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5uioe_
  • Heterogens: LG3, 8DM, NAP, BME, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5uioA (A:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uioA (A:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5uioB (B:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uioB (B:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerr
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5uioC (C:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uioC (C:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerr
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5uioD (D:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uioD (D:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerr
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >5uioE (E:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerrgggghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uioE (E:)
    mmisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkn
    iilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaev
    egdthfpdyepddwesvfsefhdadaqnshsycfeilerr