PDB entry 5ugh

View 5ugh on RCSB PDB site
Description: Crystal structure of Mat2a bound to the allosteric inhibitor PF-02929366
Class: transferase
Keywords: Mat2A, SAM, methionine adenosyltransferase, TRANSFERASE
Deposited on 2017-01-08, released 2017-05-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-07-12, with a file datestamp of 2017-07-07.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ugha1, d5ugha2, d5ugha3
  • Chain 'B':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ughb1, d5ughb2, d5ughb3
  • Chain 'C':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ughc1, d5ughc2, d5ughc3
  • Chain 'D':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ughd1, d5ughd2, d5ughd3
  • Heterogens: 8AJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ughA (A:)
gsmngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacet
vaktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdia
qgvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrp
dsktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylde
dtiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaa
rwvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpg
vivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >5ughA (A:)
fieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillagei
tsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqsedigagdqglmfgyatd
eteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtiv
isvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggpdagltgrki
ivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaigvsh
plsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfp
wevpkklky

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ughB (B:)
gsmngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacet
vaktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdia
qgvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrp
dsktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylde
dtiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaa
rwvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpg
vivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >5ughB (B:)
afieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillage
itsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdqglmfgyatdetee
cmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivisvq
hdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggpdagltgrkiivdt
yggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaigvshplsi
sifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpwevp
kklky

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5ughC (C:)
gsmngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacet
vaktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdia
qgvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrp
dsktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylde
dtiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaa
rwvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpg
vivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >5ughC (C:)
eegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageits
raavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqseedigagdqglmfgyatde
teecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivi
svqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggpdagltgrkii
vdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaigvshp
lsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpw
evpkklky

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5ughD (D:)
gsmngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacet
vaktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdia
qgvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrp
dsktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylde
dtiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaa
rwvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpg
vivrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >5ughD (D:)
ieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageit
sraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqedigagdqglmfgyatdete
ecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivisv
qhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggpdagltgrkiivd
tyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaigvshpls
isifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpwev
pkklky