PDB entry 5ugf

View 5ugf on RCSB PDB site
Description: Crystal structure of human purine nucleoside phosphorylase (F159Y) mutant complexed with DADMe-ImmG and phosphate
Class: transferase/transferase inhibitor
Keywords: phosphorylase, inhibitor, transition state analogue, purine salvage pathway, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2017-01-08, released 2017-06-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (31-End)
      • conflict (81)
      • engineered mutation (189)
    Domains in SCOPe 2.08: d5ugfa_
  • Chain 'B':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (31-End)
      • expression tag (30)
      • conflict (81)
      • engineered mutation (189)
    Domains in SCOPe 2.08: d5ugfb1, d5ugfb2
  • Chain 'C':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (31-End)
      • expression tag (29-30)
      • conflict (81)
      • engineered mutation (189)
    Domains in SCOPe 2.08: d5ugfc1, d5ugfc2
  • Chain 'D':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (31-End)
      • conflict (81)
      • engineered mutation (189)
    Domains in SCOPe 2.08: d5ugfd_
  • Chain 'E':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (31-End)
      • expression tag (30)
      • conflict (81)
      • engineered mutation (189)
    Domains in SCOPe 2.08: d5ugfe1, d5ugfe2
  • Chain 'F':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (31-End)
      • expression tag (30)
      • conflict (81)
      • engineered mutation (189)
    Domains in SCOPe 2.08: d5ugff1, d5ugff2
  • Heterogens: PO4, IM5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5ugfA (A:)
    hhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrpqvai
    icgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrfhmye
    gyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrg
    pnderfgdrypamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvaecrvl
    qklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagkqaaq
    kleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ugfA (A:)
    mengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprst
    vpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaaggl
    npkfevgdimlirdhinlpgfsgqnplrgpnderfgdrypamsdaydrtmrqralstwkq
    mgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfsl
    itnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5ugfB (B:)
    hhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrpqvai
    icgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrfhmye
    gyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrg
    pnderfgdrypamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvaecrvl
    qklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagkqaaq
    kleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ugfB (B:)
    lmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprs
    tvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagg
    lnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrypamsdaydrtmrqralstwk
    qmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfs
    litnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5ugfC (C:)
    hhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrpqvai
    icgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrfhmye
    gyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrg
    pnderfgdrypamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvaecrvl
    qklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagkqaaq
    kleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ugfC (C:)
    tlmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfpr
    stvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaag
    glnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrypamsdaydrtmrqralstw
    kqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgf
    slitnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5ugfD (D:)
    hhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrpqvai
    icgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrfhmye
    gyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrg
    pnderfgdrypamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvaecrvl
    qklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagkqaaq
    kleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ugfD (D:)
    mengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprst
    vpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaaggl
    npkfevgdimlirdhinlpgfsgqnplrgpnderfgdrypamsdaydrtmrqralstwkq
    mgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfsl
    itnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >5ugfE (E:)
    hhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrpqvai
    icgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrfhmye
    gyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrg
    pnderfgdrypamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvaecrvl
    qklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagkqaaq
    kleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ugfE (E:)
    lmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprs
    tvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagg
    lnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrypamsdaydrtmrqralstwk
    qmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfs
    litnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >5ugfF (F:)
    hhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrpqvai
    icgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrfhmye
    gyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqnplrg
    pnderfgdrypamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvaecrvl
    qklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanheevlaagkqaaq
    kleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ugfF (F:)
    lmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprs
    tvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagg
    lnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrypamsdaydrtmrqralstwk
    qmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfs
    litnkvimdyeslekanheevlaagkqaaqkleqfvsilmasiplpd