PDB entry 5uch

View 5uch on RCSB PDB site
Description: Hsp90b N-terminal domain with inhibitors
Class: Chaperone/Inhibitor
Keywords: Hsp90, inhibitor, Chaperone-Inhibitor complex
Deposited on 2016-12-22, released 2018-01-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-03-07, with a file datestamp of 2018-03-02.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: heat shock protein hsp 90-beta
    Species: Homo sapiens [TaxId:9606]
    Gene: HSP90AB1, HSP90B, HSPC2, HSPCB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08238 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d5ucha1, d5ucha2
  • Chain 'B':
    Compound: heat shock protein hsp 90-beta
    Species: Homo sapiens [TaxId:9606]
    Gene: HSP90AB1, HSP90B, HSPC2, HSPCB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uchb_
  • Chain 'C':
    Compound: heat shock protein hsp 90-beta
    Species: Homo sapiens [TaxId:9606]
    Gene: HSP90AB1, HSP90B, HSPC2, HSPCB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08238 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d5uchc1, d5uchc2
  • Chain 'D':
    Compound: heat shock protein hsp 90-beta
    Species: Homo sapiens [TaxId:9606]
    Gene: HSP90AB1, HSP90B, HSPC2, HSPCB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uchd_
  • Heterogens: 871, GOL, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uchA (A:)
ghmpeevhhgeeevetfafqaeiaqlmsliintfysnkeiflrelisnasdaldkiryes
ltdpskldsgkelkidiipnpqertltlvdtgigmtkadlinnlgtiaksgtkafmealq
agadismigqfgvgfysaylvaekvvvitkhnddeqyawessaggsftvradhgepigrg
tkvilhlkedqteyleerrvkevvkkhsqfigypitlyle

    Sequence, based on observed residues (ATOM records): (download) 
    >5uchA (A:)
ghmpeevhhgeeevetfafqaeiaqlmsliintfysnkeiflrelisnasdaldkiryes
ltdpskldsgkelkidiipnpqertltlvdtgigmtkadlinnlgtiaksgtkafmealq
agadismigqfgvgfysaylvaekvvvitkhnddeqyawessaggsftvradhgepigrg
tkvilhlkedqteyleerrvkevvkkhsqfigypitlyl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uchB (B:)
ghmpeevhhgeeevetfafqaeiaqlmsliintfysnkeiflrelisnasdaldkiryes
ltdpskldsgkelkidiipnpqertltlvdtgigmtkadlinnlgtiaksgtkafmealq
agadismigqfgvgfysaylvaekvvvitkhnddeqyawessaggsftvradhgepigrg
tkvilhlkedqteyleerrvkevvkkhsqfigypitlyle

    Sequence, based on observed residues (ATOM records): (download) 
    >5uchB (B:)
eevetfafqaeiaqlmsliintfysnkeiflrelisnasdaldkiryesltdpskldsgk
elkidiipnpqertltlvdtgigmtkadlinnlgtiaksgtkafmealqagadismigqf
gvgfysaylvaekvvvitkhnddeqyawessaggsftvradhgepigrgtkvilhlkedq
teyleerrvkevvkkhsqfigypitlyl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5uchC (C:)
ghmpeevhhgeeevetfafqaeiaqlmsliintfysnkeiflrelisnasdaldkiryes
ltdpskldsgkelkidiipnpqertltlvdtgigmtkadlinnlgtiaksgtkafmealq
agadismigqfgvgfysaylvaekvvvitkhnddeqyawessaggsftvradhgepigrg
tkvilhlkedqteyleerrvkevvkkhsqfigypitlyle

    Sequence, based on observed residues (ATOM records): (download) 
    >5uchC (C:)
ghmpeevhhgeeevetfafqaeiaqlmsliintfysnkeiflrelisnasdaldkiryes
ltdpskldsgkelkidiipnpqertltlvdtgigmtkadlinnlgtiaksgtkafmealq
agadismigqfgvgfysaylvaekvvvitkhnddeqyawessaggsftvradhgepigrg
tkvilhlkedqteyleerrvkevvkkhsqfigypitlyl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5uchD (D:)
ghmpeevhhgeeevetfafqaeiaqlmsliintfysnkeiflrelisnasdaldkiryes
ltdpskldsgkelkidiipnpqertltlvdtgigmtkadlinnlgtiaksgtkafmealq
agadismigqfgvgfysaylvaekvvvitkhnddeqyawessaggsftvradhgepigrg
tkvilhlkedqteyleerrvkevvkkhsqfigypitlyle

    Sequence, based on observed residues (ATOM records): (download) 
    >5uchD (D:)
evetfafqaeiaqlmsliintfysnkeiflrelisnasdaldkiryesltdpskldsgke
lkidiipnpqertltlvdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfg
vgfysaylvaekvvvitkhnddeqyawessaggsftvradhgepigrgtkvilhlkedqt
eyleerrvkevvkkhsqfigypitlyl