PDB entry 5uau

View 5uau on RCSB PDB site
Description: Structure of human PYCR-1 complexed with proline
Class: oxidoreductase
Keywords: amino-acid biosynthesis, oxidoreductase, proline biosynthesis
Deposited on 2016-12-20, released 2017-03-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uaua1, d5uaua2
  • Chain 'B':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (19-21)
    Domains in SCOPe 2.08: d5uaub1, d5uaub2, d5uaub3
  • Chain 'C':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (21)
    Domains in SCOPe 2.08: d5uauc1, d5uauc2, d5uauc3
  • Chain 'D':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uaud1, d5uaud2
  • Chain 'E':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uaue1, d5uaue2
  • Heterogens: PRO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uauA (A:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uauA (A:)
msvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnketv
qhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvirc
mtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpay
aftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatih
alhvlesggfrsllinaveascirtrelqsmadq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uauB (B:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uauB (B:)
fqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnk
etvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprv
ircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsg
payaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspgga
tihalhvlesggfrsllinaveascirtrelqsmadq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5uauC (C:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uauC (C:)
smsvgfigagqlafalakgftaagvlaahkimasspdmtvsalrkmgvkltphnketvqh
sdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvircmt
ntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpayaf
taldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatihal
hvlesggfrsllinaveascirtrelqsmadq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5uauD (D:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uauD (D:)
msvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnketv
qhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvirc
mtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpay
aftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatih
alhvlesggfrsllinaveascirtrelqsmadqe

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5uauE (E:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uauE (E:)
msvgfigagqlafalakgftaagvlaahkimasspdmlrkmgvkltphnketvqhsdvlf
lavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvircmtntpvv
vregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpayaftalda
ladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatihalhvles
ggfrsllinaveascirtrelqsmadq