PDB entry 5uab

View 5uab on RCSB PDB site
Description: MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody
Class: transferase/inhibitor
Keywords: MET, Tyrosine Kinase, Inhibitor, Antitumor, TRANSFERASE-INHIBITOR complex
Deposited on 2016-12-19, released 2017-05-31
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-05-31, with a file datestamp of 2017-05-26.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hepatocyte growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: MET
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5uaba_
  • Heterogens: 84M, GOL, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5uabA (A:)
    gamgsqvqypltdmspiltsgdsdisspllqntvhidlsalnpelvqavqhvvigpssli
    vhfnevigrghfgcvyhgtlldndgkkihcavkslnritdigevsqfltegiimkdfshp
    nvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptvkdligfglqvakgmkylas
    kkfvhrdlaarncmldekftvkvadfglardmydkeyysvhnktgaklpvkwmaleslqt
    qkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdplyevml
    kcwhpkaemrpsfselvsrisaifstfigehyvhvnatyvnvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uabA (A:)
    tdmspinpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlhcavkslnvsqflte
    giimkdfshpnvlsllgiclplvvlpymkhgdlrnfirnethnptvkdligfglqvakgm
    kylaskkfvhrdlaarncmldekftvkvadfglardmydkeyysvhnktgaklpvkwmal
    eslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdpl
    yevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnatyvnvk