PDB entry 5u94

View 5u94 on RCSB PDB site
Description: Crystal structure of the Mycobacterium tuberculosis PASTA kinase PknB in complex with the potential theraputic kinase inhibitor GSK690693.
Class: Transferase/Transferase Inhibitor
Keywords: Kinase, inhibitor, transferase, Transferase-Transferase Inhibitor complex
Deposited on 2016-12-15, released 2017-12-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase pknb
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: pknB, Rv0014c, MTCY10H4.14c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5u94a_
  • Heterogens: G93, GOL, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5u94A (A:)
gplgsmttpshlsdryelgeilgfggmsevhlardlrlhrdvavkvlradlardpsfylr
frreaqnaaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkra
ieviadacqalnfshqngiihrdvkpanimisatnavkvmdfgiaraiadsgnsvtqtaa
vigtaqylspeqargdsvdarsdvyslgcvlyevltgeppftgdspvsvayqhvredpip
psarheglsadldavvlkalaknpenryqtaaemradlvrvhnge

    Sequence, based on observed residues (ATOM records): (download) 
    >5u94A (A:)
tpshlsdryelgeilgfggmsevhlardlrlhrdvavkvlradlardpsfylrfrreaqn
aaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkraieviada
cqalnfshqngiihrdvkpanimisatnavkvmdfgiaraiigtaqylspeqargdsvda
rsdvyslgcvlyevltgeppftgdspvsvayqhvredpippsarheglsadldavvlkal
aknpenryqtaaemradlvrvhn