PDB entry 5u7k

View 5u7k on RCSB PDB site
Description: PDE2 catalytic domain complexed with inhibitors
Class: Hydrolase/Hydrolase Inhibitor
Keywords: PDE2, SBDD, inhibitor, phosphodiesterase, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2016-12-12, released 2017-06-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00408 (4-End)
      • expression tag (2-3)
    Domains in SCOPe 2.07: d5u7ka1, d5u7ka2
  • Chain 'B':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00408 (4-End)
      • expression tag (1-3)
    Domains in SCOPe 2.07: d5u7kb1, d5u7kb2
  • Chain 'C':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5u7kc_
  • Chain 'D':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5u7kd_
  • Heterogens: ZN, MG, 7Y1, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5u7kA (A:)
gsamddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnyki
dcptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscm
chdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdy
qrmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtk
gwkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykll
qdlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5u7kA (A:)
amddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidc
ptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmch
dldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqr
mldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgw
kttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqd
lfpkaaelyervasnrehwtkvshkftirglpsnnsldfl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5u7kB (B:)
gsamddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnyki
dcptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscm
chdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdy
qrmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtk
gwkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykll
qdlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5u7kB (B:)
samddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykid
cptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmc
hdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyq
rmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkg
wkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllq
dlfpkaaelyervasnrehwtkvshkftirglpsnnsldflde

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5u7kC (C:)
gsamddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnyki
dcptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscm
chdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdy
qrmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtk
gwkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykll
qdlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5u7kC (C:)
deytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptl
arfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdld
hrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmld
lmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwktt
rkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfp
kaaelyervasnrehwtkvshkftirglpsnnsldflde

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5u7kD (D:)
gsamddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnyki
dcptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscm
chdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdy
qrmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtk
gwkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykll
qdlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5u7kD (D:)
iqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptlarfclmvkkg
yrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdldhrgtnnsfqv
asksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmldlmrdiilatd
lahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwkttrkiaeliyke
ffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfpkaaelyerva
snrehwtkvshkftirglpsnnsldfl