PDB entry 5u7i

View 5u7i on RCSB PDB site
Description: PDE2 catalytic domain complexed with inhibitors
Class: Hydrolase/Hydrolase Inhibitor
Keywords: PDE2, SBDD, inhibitor, phosphodiesterase, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2016-12-12, released 2017-06-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-06-28, with a file datestamp of 2017-06-23.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5u7ia_
  • Chain 'B':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5u7ib_
  • Chain 'C':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5u7ic_
  • Chain 'D':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5u7id_
  • Heterogens: 7XS, ZN, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5u7iA (A:)
gsamddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnyki
dcptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscm
chdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdy
qrmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtk
gwkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykll
qdlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5u7iA (A:)
ddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcpt
larfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdl
dhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrml
dlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwkt
trkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlf
pkaaelyervasnrehwtkvshkftirglpsnnsldfl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5u7iB (B:)
gsamddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnyki
dcptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscm
chdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdy
qrmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtk
gwkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykll
qdlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5u7iB (B:)
deytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptl
arfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdld
hrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmld
lmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwktt
rkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfp
kaaelyervasnrehwtkvshkftirglpsnnsldf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5u7iC (C:)
gsamddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnyki
dcptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscm
chdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdy
qrmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtk
gwkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykll
qdlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5u7iC (C:)
iqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptlarfclmvkkg
yrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdldhrgtnnsfqv
asksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmldlmrdiilatd
lahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwkttrkiaeliyke
ffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfpkaaelyerva
snrehwtkvshkftirglpsnnsldfl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5u7iD (D:)
gsamddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnyki
dcptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscm
chdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdy
qrmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtk
gwkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykll
qdlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5u7iD (D:)
iqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptlarfclmvkkg
yrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdldhrgtnnsfqv
asksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmldlmrdiilatd
lahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwkttrkiaeliyke
ffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfpkaaelyerva
snrehwtkvshkftirglpsnnsl