PDB entry 5u28

View 5u28 on RCSB PDB site
Description: BRD4 first bromodomain (BD1) in complex with dual PI3 kinase inhibitor SF2523
Class: transcription regulator/inhibitor
Keywords: bromodomain, transcription, inhibitor, epigenetics, TRANSCRIPTION REGULATOR-INHIBITOR complex
Deposited on 2016-11-30, released 2017-02-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-03-01, with a file datestamp of 2017-02-24.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d5u28a1, d5u28a2
  • Heterogens: 82V, PEG, SCN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5u28A (A:)
anppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpteeteimivqakgrg

    Sequence, based on observed residues (ATOM records): (download) 
    >5u28A (A:)
anppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpteeteimivqa