PDB entry 5u26
View 5u26 on RCSB PDB site
Description: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor
Class: oxidoreductase
Keywords: DHFR, Folate, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID, OXIDOREDUCTASE
Deposited on
2016-11-29, released
2016-12-21
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-22, with a file datestamp of
2017-11-17.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.36
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: dihydrofolate reductase
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: folA, folA_1, BN1213_03327, BN1303_00864, ERS007661_02580, ERS007663_03946, ERS007665_02766, ERS007741_00337, ERS013471_00736, ERS023446_01268, ERS024213_02711, ERS027644_04978, ERS027646_03318, ERS027653_04780, ERS027654_00299, ERS027656_00246, ERS027659_04151, ERS027661_03595, ERS027666_04095, ERS031537_04020, ERS124361_01473, RN05_2938
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5u26a1, d5u26a2 - Heterogens: MMV, NAP, EDO, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5u26A (A:)
mgsshhhhhhssglvprgshmvgliwaqatsgvigrggdipwrlpedqahfreitmghti
vmgrrtwdslpakvrplpgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvy
alalpyatrcevtevdiglpreagdalapvldetwrgetgewrfsrsglryrlysyhrs
Sequence, based on observed residues (ATOM records): (download)
>5u26A (A:)
lvprgshmvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpak
vrplpgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevt
evdiglpreagdalapvldetwrgetgewrfsrsglryrlysyhrs