PDB entry 5tzu

View 5tzu on RCSB PDB site
Description: Crystal structure of human CD47 ECD bound to Fab of B6H12.2
Class: immune system
Keywords: antigen-Fab complex, immunoglobulin, IMMUNE SYSTEM
Deposited on 2016-11-22, released 2017-03-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: leukocyte surface antigen cd47
    Species: Homo sapiens [TaxId:9606]
    Gene: CD47, MER6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08722 (0-End)
      • engineered mutation (14)
  • Chain 'H':
    Compound: Heavy Chain of Fab B6H12.2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5TZU (0-End)
    Domains in SCOPe 2.08: d5tzuh_
  • Chain 'L':
    Compound: Light Chain of Fab B6H12.2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5TZU (0-End)
    Domains in SCOPe 2.08: d5tzul1, d5tzul2
  • Heterogens: SO4, ACT, NAG, GOL, HOH

PDB Chain Sequences:

  • Chain 'C':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5tzuH (H:)
evklvesggdlvkpggslklscaasgftfsgygmswvrqtpdkrlewvatitsggtytyy
pdsvkgrftisrdnakntlylqidslksedtaiyfcarslagnamdywgqgtsvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkschhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5tzuH (H:)
evklvesggdlvkpggslklscaasgftfsgygmswvrqtpdkrlewvatitsggtytyy
pdsvkgrftisrdnakntlylqidslksedtaiyfcarslagnamdywgqgtsvtvssas
tkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5tzuL (L:)
divmtqspatlsvtpgdrvslscrasqtisdylhwyqqkshesprllikfasqsisgips
rfsgsgsgsdftlsinsvepedvgvyycqnghgfprtfgggtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >5tzuL (L:)
divmtqspatlsvtpgdrvslscrasqtisdylhwyqqkshesprllikfasqsisgips
rfsgsgsgsdftlsinsvepedvgvyycqnghgfprtfgggtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge