PDB entry 5tzh

View 5tzh on RCSB PDB site
Description: CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 3,3-difluoro-1-[(4-fluorophenyl)carbonyl]-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine
Class: hydrolase/hydrolase inhibitor
Keywords: phosphodiesterase, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2016-11-21, released 2017-02-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00408 (3-End)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d5tzha1, d5tzha2
  • Chain 'B':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00408 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.08: d5tzhb1, d5tzhb2
  • Chain 'C':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5tzhc_
  • Chain 'D':
    Compound: cGMP-dependent 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5tzhd_
  • Heterogens: 7OP, ZN, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5tzhA (A:)
samddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykid
cptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmc
hdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyq
rmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkg
wkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllq
dlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5tzhA (A:)
samddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykid
cptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmc
hdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyq
rmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkg
wkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllq
dlfpkaaelyervasnrehwtkvshkftirglpsnnsldfl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5tzhB (B:)
samddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykid
cptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmc
hdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyq
rmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkg
wkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllq
dlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5tzhB (B:)
mddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcp
tlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchd
ldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrm
ldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwk
ttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdl
fpkaaelyervasnrehwtkvshkftirglpsnnsldfl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5tzhC (C:)
samddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykid
cptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmc
hdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyq
rmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkg
wkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllq
dlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5tzhC (C:)
iqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptlarfclmvkkg
yrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdldhrgtnnsfqv
asksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmldlmrdiilatd
lahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwkttrkiaeliyke
ffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfpkaaelyerva
snrehwtkvshkftirglpsnnsldfl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5tzhD (D:)
samddeytkllhdgiqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykid
cptlarfclmvkkgyrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmc
hdldhrgtnnsfqvasksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyq
rmldlmrdiilatdlahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkg
wkttrkiaeliykeffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllq
dlfpkaaelyervasnrehwtkvshkftirglpsnnsldfldee

    Sequence, based on observed residues (ATOM records): (download) 
    >5tzhD (D:)
iqpvaaidsnfasftytprslpeddtsmailsmlqdmnfinnykidcptlarfclmvkkg
yrdppyhnwmhafsvshfcyllyknleltnyledieifalfiscmchdldhrgtnnsfqv
asksvlaalyssegsvmerhhfaqaiailnthgcnifdhfsrkdyqrmldlmrdiilatd
lahhlrifkdlqkmaevgydrnnkqhhrlllcllmtscdlsdqtkgwkttrkiaeliyke
ffsqgdlekamgnrpmemmdrekayipelqisfmehiampiykllqdlfpkaaelyerva
snrehwtkvshkftirglpsnnsldfl