PDB entry 5tw7

View 5tw7 on RCSB PDB site
Description: Crystal structure of a GMP synthase (glutamine-hydrolyzing) from Neisseria gonorrhoeae
Class: ligase
Keywords: Neisseria gonorrhoeae, GMP, glutamine, structural genomics, NIAID, Seattle Structural Genomics Center for Infectious Disease, SSGCID, LIGASE
Deposited on 2016-11-11, released 2016-11-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GMP synthase [glutamine-hydrolyzing]
    Species: NEISSERIA GONORRHOEAE [TaxId:485]
    Gene: guaA, NGK_2643
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5tw7a1, d5tw7a2, d5tw7a3
  • Chain 'B':
    Compound: GMP synthase [glutamine-hydrolyzing]
    Species: NEISSERIA GONORRHOEAE [TaxId:485]
    Gene: guaA, NGK_2643
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5tw7b1, d5tw7b2, d5tw7b3
  • Chain 'C':
    Compound: GMP synthase [glutamine-hydrolyzing]
    Species: NEISSERIA GONORRHOEAE [TaxId:485]
    Gene: guaA, NGK_2643
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5tw7c1, d5tw7c2, d5tw7c3, d5tw7c4
  • Chain 'D':
    Compound: GMP synthase [glutamine-hydrolyzing]
    Species: NEISSERIA GONORRHOEAE [TaxId:485]
    Gene: guaA, NGK_2643
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5tw7d1, d5tw7d2, d5tw7d3
  • Chain 'E':
    Compound: GMP synthase [glutamine-hydrolyzing]
    Species: NEISSERIA GONORRHOEAE [TaxId:485]
    Gene: guaA, NGK_2643
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5tw7e1, d5tw7e2, d5tw7e3
  • Chain 'F':
    Compound: GMP synthase [glutamine-hydrolyzing]
    Species: NEISSERIA GONORRHOEAE [TaxId:485]
    Gene: guaA, NGK_2643
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5tw7f1, d5tw7f2, d5tw7f3, d5tw7f4
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5tw7A (A:)
mahhhhhhmtqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiil
sggpnsvyesdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktid
sgltrgiqddapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhp
evthtkqgrallnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssv
aaalihraigdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvt
dpekkrkiigaefievfdaeekkltnakwlaqgtiypdviesagaktkkahaikshhnvg
glpenmklklleplrdlfkdevrelgvalglpremvyrhpfpgpglgvrilgevkkeyad
llrqaddifiqelrnttdengtswydltsqafavflpvksvgvmgdgrtydyvvalravi
tsdfmtahwaelpysllgrvsnriinevkginrvvydvsgkppatiewe

    Sequence, based on observed residues (ATOM records): (download) 
    >5tw7A (A:)
qdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiilsggpnsvyes
dyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktidsgltrgiqdd
apntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhpevthtkqgra
llnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssvaaalihraig
dqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvtdpekkrkiig
aefievfdaeekkltnakwlaqgtiypdviklklleplrdlfkdevrelgvalglpremv
yrhpfpgpglgvrilgevkkeyadllrqaddifiqelrnttdengtswydltsqafavfl
pvksvgvgrtydyvvalravitsdfmtahwaelpysllgrvsnriinevkginrvvydvs
gkppatiewe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5tw7B (B:)
mahhhhhhmtqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiil
sggpnsvyesdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktid
sgltrgiqddapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhp
evthtkqgrallnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssv
aaalihraigdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvt
dpekkrkiigaefievfdaeekkltnakwlaqgtiypdviesagaktkkahaikshhnvg
glpenmklklleplrdlfkdevrelgvalglpremvyrhpfpgpglgvrilgevkkeyad
llrqaddifiqelrnttdengtswydltsqafavflpvksvgvmgdgrtydyvvalravi
tsdfmtahwaelpysllgrvsnriinevkginrvvydvsgkppatiewe

    Sequence, based on observed residues (ATOM records): (download) 
    >5tw7B (B:)
tqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiilsggpnsvye
sdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktidsgltrgiqd
dapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhpevthtkqgr
allnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssvaaalihrai
gdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvtdpekkrkii
gaefievfdaeekkltnakwlaqgtiypdviklklleplrdlfkdevrelgvalglprem
vyrhpfpgpglgvrilgevkkeyadllrqaddifiqelrnttdengtswydltsqafavf
lpvksvgvrtydyvvalravitsdfmtahwaelpysllgrvsnriinevkginrvvydvs
gkppatiewe

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5tw7C (C:)
mahhhhhhmtqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiil
sggpnsvyesdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktid
sgltrgiqddapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhp
evthtkqgrallnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssv
aaalihraigdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvt
dpekkrkiigaefievfdaeekkltnakwlaqgtiypdviesagaktkkahaikshhnvg
glpenmklklleplrdlfkdevrelgvalglpremvyrhpfpgpglgvrilgevkkeyad
llrqaddifiqelrnttdengtswydltsqafavflpvksvgvmgdgrtydyvvalravi
tsdfmtahwaelpysllgrvsnriinevkginrvvydvsgkppatiewe

    Sequence, based on observed residues (ATOM records): (download) 
    >5tw7C (C:)
mtqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiilsggpnsvy
esdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktidsgltrgiq
ddapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhpevthtkqg
rallnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssvaaalihra
igdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvtdpekkrki
igaefievfdaeekkltnakwlaqgtiypdvieklklleplrdlfkdevrelgvalglpr
emvyrhpfpgpglgvrilgevkkeyadllrqaddifiqelrnttdengtswydltsqafa
vflpvksvgvrtydyvvalravitsdfmtahwaelpysllgrvsnriinevkginrvvyd
vsgkppatiewe

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5tw7D (D:)
mahhhhhhmtqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiil
sggpnsvyesdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktid
sgltrgiqddapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhp
evthtkqgrallnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssv
aaalihraigdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvt
dpekkrkiigaefievfdaeekkltnakwlaqgtiypdviesagaktkkahaikshhnvg
glpenmklklleplrdlfkdevrelgvalglpremvyrhpfpgpglgvrilgevkkeyad
llrqaddifiqelrnttdengtswydltsqafavflpvksvgvmgdgrtydyvvalravi
tsdfmtahwaelpysllgrvsnriinevkginrvvydvsgkppatiewe

    Sequence, based on observed residues (ATOM records): (download) 
    >5tw7D (D:)
tqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiilsggpnsvye
sdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktidsgltrgiqd
dapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhpevthtkqgr
allnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssvaaalihrai
gdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvtdpekkrkii
gaefievfdaeekkltnakwlaqgtiypdvilklleplrdlfkdevrelgvalglpremv
yrhpfpgpglgvrilgevkkeyadllrqaddifiqelrnttdengtswydltsqafavfl
pvksvgvdgrtydyvvalravitsdfmtahwaelpysllgrvsnriinevkginrvvydv
sgkppatiewe

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5tw7E (E:)
mahhhhhhmtqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiil
sggpnsvyesdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktid
sgltrgiqddapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhp
evthtkqgrallnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssv
aaalihraigdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvt
dpekkrkiigaefievfdaeekkltnakwlaqgtiypdviesagaktkkahaikshhnvg
glpenmklklleplrdlfkdevrelgvalglpremvyrhpfpgpglgvrilgevkkeyad
llrqaddifiqelrnttdengtswydltsqafavflpvksvgvmgdgrtydyvvalravi
tsdfmtahwaelpysllgrvsnriinevkginrvvydvsgkppatiewe

    Sequence, based on observed residues (ATOM records): (download) 
    >5tw7E (E:)
qdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiilsggpnsvyes
dyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktidsgltrgiqdd
apntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhpevthtkqgra
llnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssvaaalihraig
dqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvtdpekkrkiig
aefievfdaeekkltnakwlaqgtiypdvilklleplrdlfkdevrelgvalglpremvy
rhpfpgpglgvrilgevkkeyadllrqaddifiqelrnttdengtswydltsqafavflp
vksvgvmrtydyvvalravitsdfmtahwaelpysllgrvsnriinevkginrvvydvsg
kppatiewe

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5tw7F (F:)
mahhhhhhmtqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiil
sggpnsvyesdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktid
sgltrgiqddapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhp
evthtkqgrallnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssv
aaalihraigdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvt
dpekkrkiigaefievfdaeekkltnakwlaqgtiypdviesagaktkkahaikshhnvg
glpenmklklleplrdlfkdevrelgvalglpremvyrhpfpgpglgvrilgevkkeyad
llrqaddifiqelrnttdengtswydltsqafavflpvksvgvmgdgrtydyvvalravi
tsdfmtahwaelpysllgrvsnriinevkginrvvydvsgkppatiewe

    Sequence, based on observed residues (ATOM records): (download) 
    >5tw7F (F:)
mtqdkilildfgsqvtrliarrvreahvycelhsfdmpldeikafnpkgiilsggpnsvy
esdyqadtgifdlgipvlgicygmqfmahhlggevqpgnqrefgyaqvktidsgltrgiq
ddapntldvwmshgdkvsklpdgfavigdtpscpiammentekqfygiqfhpevthtkqg
rallnrfvldicgaqpgwtmpnyieeavakireqvgsdevilglsggvdssvaaalihra
igdqltcvfvdhgllrlnegkmvmdmfarnlgvkvihvdaegqfmaklagvtdpekkrki
igaefievfdaeekkltnakwlaqgtiypdviklklleplrdlfkdevrelgvalglpre
mvyrhpfpgpglgvrilgevkkeyadllrqaddifiqelrnttdengtswydltsqafav
flpvksvgvtydyvvalravitsdfmtahwaelpysllgrvsnriinevkginrvvydvs
gkppatiewe