PDB entry 5tvc
View 5tvc on RCSB PDB site
Description: Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)
Class: acetylcholine-binding protein
Keywords: nicotinic, acetylcholine, AChBP, chimeric protein, ACETYLCHOLINE-BINDING PROTEIN
Deposited on
2016-11-08, released
2016-11-30
The last revision prior to the SCOPe 2.06 freeze date was dated
2016-11-30, with a file datestamp of
2016-11-25.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Soluble acetylcholine receptor,Neuronal acetylcholine receptor subunit alpha-3 chimera
Species: Homo sapiens [TaxId:9606]
Gene: CHRNA3, NACHRA3
Database cross-references and differences (RAF-indexed):
- Uniprot Q8WSF8 (9-189)
- expression tag (6-8)
- engineered mutation (63)
- Uniprot P32297 (190-205)
- Uniprot Q8WSF8 (206-End)
- engineered mutation (207)
Domains in SCOPe 2.06: d5tvca1, d5tvca2 - Chain 'B':
Compound: Soluble acetylcholine receptor,Neuronal acetylcholine receptor subunit alpha-3 chimera
Species: Homo sapiens [TaxId:9606]
Gene: CHRNA3, NACHRA3
Database cross-references and differences (RAF-indexed):
- Uniprot Q8WSF8 (9-189)
- Uniprot P32297 (190-205)
- Uniprot Q8WSF8 (206-End)
- engineered mutation (207)
Domains in SCOPe 2.06: d5tvcb_ - Chain 'C':
Compound: Soluble acetylcholine receptor,Neuronal acetylcholine receptor subunit alpha-3 chimera
Species: Homo sapiens [TaxId:9606]
Gene: CHRNA3, NACHRA3
Database cross-references and differences (RAF-indexed):
- Uniprot Q8WSF8 (9-189)
- expression tag (5-8)
- engineered mutation (63)
- Uniprot P32297 (190-205)
- Uniprot Q8WSF8 (206-End)
- engineered mutation (207)
Domains in SCOPe 2.06: d5tvcc1, d5tvcc2 - Chain 'D':
Compound: Soluble acetylcholine receptor,Neuronal acetylcholine receptor subunit alpha-3 chimera
Species: Homo sapiens [TaxId:9606]
Gene: CHRNA3, NACHRA3
Database cross-references and differences (RAF-indexed):
- Uniprot Q8WSF8 (Start-189)
- Uniprot P32297 (190-205)
- Uniprot Q8WSF8 (206-End)
- engineered mutation (207)
Domains in SCOPe 2.06: d5tvcd_ - Chain 'E':
Compound: Soluble acetylcholine receptor,Neuronal acetylcholine receptor subunit alpha-3 chimera
Species: Homo sapiens [TaxId:9606]
Gene: CHRNA3, NACHRA3
Database cross-references and differences (RAF-indexed):
- Uniprot Q8WSF8 (9-189)
- expression tag (3-8)
- engineered mutation (63)
- Uniprot P32297 (190-205)
- Uniprot Q8WSF8 (206-End)
- engineered mutation (207)
Domains in SCOPe 2.06: d5tvce1, d5tvce2 - Heterogens: SO4, 1PE, 7LB, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5tvcA (A:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqykhdikyncceeiypdvvlvvkfrerragngffrnlfdsr
Sequence, based on observed residues (ATOM records): (download)
>5tvcA (A:)
dklhsqanlmrlksdlfypgptkddpltvtlgftlqdivkadsstnevdlvyweqqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqy
khdikyncceeiypdvvlvvkfrerragngf
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5tvcB (B:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqykhdikyncceeiypdvvlvvkfrerragngffrnlfdsr
Sequence, based on observed residues (ATOM records): (download)
>5tvcB (B:)
hsqanlmrlksdlfypgptkddpltvtlgftlqdivkadsstnevdlvyweqqrwklnsl
mwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqrlsf
mcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqykhd
ikyncceeiypdvvlvvkfre
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5tvcC (C:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqykhdikyncceeiypdvvlvvkfrerragngffrnlfdsr
Sequence, based on observed residues (ATOM records): (download)
>5tvcC (C:)
ddklhsqanlmrlksdlfypgptkddpltvtlgftlqdivkadsstnevdlvyweqqrwk
lnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaq
rlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatq
ykhdieeiypdvvlvvkfrer
- Chain 'D':
Sequence, based on SEQRES records: (download)
>5tvcD (D:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqykhdikyncceeiypdvvlvvkfrerragngffrnlfdsr
Sequence, based on observed residues (ATOM records): (download)
>5tvcD (D:)
sqanlmrlksdlypgptkddpltvtlgftlqdivkadsstnevdlvyweqqrwklnslmw
dpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqrlsfmc
dptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqykhdik
yncceeiypdvvlvvkfre
- Chain 'E':
Sequence, based on SEQRES records: (download)
>5tvcE (E:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqykhdikyncceeiypdvvlvvkfrerragngffrnlfdsr
Sequence, based on observed residues (ATOM records): (download)
>5tvcE (E:)
ddddklhsqanlmrlksdlfypgptkddpltvtlgftlqdivkadsstnevdlvyweqqr
wklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfip
aqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsa
tqykhdikyncceeiypdvvlvvkfrer