PDB entry 5to1

View 5to1 on RCSB PDB site
Description: HtrA2 exposed (L266R, F303A) mutant
Class: hydrolase
Keywords: Serine Protease, Parkinson Disease, Mitochondria, PDZ Dynamics, hydrolase
Deposited on 2016-10-15, released 2017-10-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-25, with a file datestamp of 2018-04-20.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine protease HTRA2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: HTRA2, OMI, PRSS25
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43464 (Start-325)
      • engineered mutation (133)
      • engineered mutation (170)
      • expression tag (326-328)
    Domains in SCOPe 2.08: d5to1a1, d5to1a2, d5to1a3
  • Heterogens: MES, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5to1A (A:)
mavpspppasprsqynfiadvvektapavvyieildrhpflgrevpisngsgfvvaadgl
ivtnahvvadrrrvrvrllsgdtyeavvtavdpvadiatlriqtkeplptlplgrsadvr
qgefvvamgspfarqntitsgivssaqrpardlglpqtnveyiqtdaaidagnsggplvn
ldgevigvntmkvtagisfaipsdrlreflhrgekknsssgisgsqrryigvmmltlsps
ilaelqlrepsfpdvqhgvlihkvilgspahraglrpgdvilaigeqmvqnaedvyeavr
tqsqlavqirrgretltlyvtpevtelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5to1A (A:)
sprsqynfiadvvektapavvyieildrhpflgrevpisngsgfvvaadglivtnahvva
drrrvrvrllsgdtyeavvtavdpvadiatlriqtkeplptlplgrsadvrqgefvvamg
spfarqntitsgivssaqrpeyiqtdaaidagnsggplvnldgevigvntmkvtagisfa
ipsdrlreflhqrryigvmmltlspsilaelqlrepsfpdvqhgvlihkvilgspahrag
lrpgdvilaigeqmvqnaedvyeavrtqsqlavqirrgretltlyvtpevteleh