PDB entry 5to0

View 5to0 on RCSB PDB site
Description: HTRA2 S276C mutant
Class: hydrolase
Keywords: Serine Protease, Parkinson Disease, Mitochondria, PDZ Dynamics, hydrolase
Deposited on 2016-10-15, released 2017-10-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine protease HTRA2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: HTRA2, OMI, PRSS25
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43464 (Start-325)
      • engineered mutation (143)
      • expression tag (326-327)
    Domains in SCOPe 2.07: d5to0a1, d5to0a2, d5to0a3
  • Heterogens: MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5to0A (A:)
mavpspppasprsqynfiadvvektapavvyieildrhpflgrevpisngsgfvvaadgl
ivtnahvvadrrrvrvrllsgdtyeavvtavdpvadiatlriqtkeplptlplgrsadvr
qgefvvamgspfalqntitsgivcsaqrpardlglpqtnveyiqtdaaidfgnsggplvn
ldgevigvntmkvtagisfaipsdrlreflhrgekknsssgisgsqrryigvmmltlsps
ilaelqlrepsfpdvqhgvlihkvilgspahraglrpgdvilaigeqmvqnaedvyeavr
tqsqlavqirrgretltlyvtpevtehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5to0A (A:)
sprsqynfiadvvektapavvyieildrhpflgrevpisngsgfvvaadglivtnahvva
drrrvrvrllsgdtyeavvtavdpvadiatlriqtkeplptlplgrsadvrqgefvvamg
spfalqntitsgivcsaqnveyiqtdaaidfgnsggplvnldgevigvntmkvtagisfa
ipsdrlreflhrrryigvmmltlspsilaelqlrevqhgvlihkvilgspahraglrpgd
vilaigeqmvqnaedvyeavrtqsqlavqirrgretltlyvtpevtehh