PDB entry 5thu

View 5thu on RCSB PDB site
Description: Crystal Structure of G304A HDAC8 in complex with M344
Class: hydrolase
Keywords: Zinc Histone Deacetylase, HYDROLASE
Deposited on 2016-09-30, released 2016-12-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (303)
      • expression tag (377)
    Domains in SCOPe 2.08: d5thua1, d5thua2
  • Chain 'B':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (303)
    Domains in SCOPe 2.08: d5thub_
  • Heterogens: ZN, K, B3N, GGG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5thuA (A:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggagynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5thuA (A:)
lvpvyiyspeyvsmcdskipkrasmvhslieayalhkqmrivkpkvasmeematfhtday
lqhlqkvsdhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckvainwsgg
whhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvsl
hkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpkav
vlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggagynlantarcwtyltg
vilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvvi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5thuB (B:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggagynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5thuB (B:)
lvpvyiyspeyvsmcdspkrasmvhslieayalhkqmrivkpkvasmeematfhtdaylq
hlqkvsqeygltegifdyaaaiggatitaaqclidgmckvainwsggwhhakkdeasgfc
ylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvslhkfspgffpgtgd
vsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpkavvlqlgadtiagdp
mcsfnmtpvgigkclkyilqwqlatlilggagynlantarcwtyltgvilgktlsseipd
hefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvv