PDB entry 5tf5

View 5tf5 on RCSB PDB site
Description: crystal structure of human kat-2 in complex with a reversible inhibitor
Class: transferase/transferase inhibitor
Keywords: NS-1502, reversible KAT-2 inhibitor, LLP, transferase-transferase inhibitor complex
Deposited on 2016-09-24, released 2016-10-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-12, with a file datestamp of 2017-07-07.
Experiment type: XRAY
Resolution: 1.81 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: AADAT, KAT2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5tf5a_
  • Chain 'B':
    Compound: kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: AADAT, KAT2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5tf5b_
  • Heterogens: 7AR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5tf5A (A:)
mnyarfitaasaarnpspirtmtdilsrgpksmislagglpnpnmfpfktavitvengkt
iqfgeemmkralqyspsagipellswlkqlqiklhnpptihyppsqgqmdlcvtsgsqqg
lckvfemiinpgdnvlldepaysgtlqslhplgcniinvasdesgivpdslrdilsrwkp
edaknpqkntpkflytvpngnnptgnsltserkkeiyelarkydfliieddpyyflqfnk
frvptflsmdvdgrviradsfskiissglrigfltgpkpliervilhiqvstlhpstfnq
lmisqllhewgeegfmahvdrvidfysnqkdailaaadkwltglaewhvpaagmflwikv
kgindvkelieekavkmgvlmlpgnafyvdssapspylrasfssaspeqmdvafqvlaql
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  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5tf5B (B:)
mnyarfitaasaarnpspirtmtdilsrgpksmislagglpnpnmfpfktavitvengkt
iqfgeemmkralqyspsagipellswlkqlqiklhnpptihyppsqgqmdlcvtsgsqqg
lckvfemiinpgdnvlldepaysgtlqslhplgcniinvasdesgivpdslrdilsrwkp
edaknpqkntpkflytvpngnnptgnsltserkkeiyelarkydfliieddpyyflqfnk
frvptflsmdvdgrviradsfskiissglrigfltgpkpliervilhiqvstlhpstfnq
lmisqllhewgeegfmahvdrvidfysnqkdailaaadkwltglaewhvpaagmflwikv
kgindvkelieekavkmgvlmlpgnafyvdssapspylrasfssaspeqmdvafqvlaql
ikesl