PDB entry 5t8g

View 5t8g on RCSB PDB site
Description: Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-oxo-4-((thiophene-2-carbonyl)oxy)butanoic acid
Class: transferase/transferase inhibitor
Keywords: transferase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2016-09-07, released 2016-10-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: malate synthase g
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: glcB, Rv1837c, MTCY1A11.06
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WK17
      • engineered mutation (618)
    Domains in SCOPe 2.08: d5t8ga_
  • Heterogens: MG, 4Z0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5t8gA (A:)
mtdrvsvgnlriarvlydfvnnealpgtdidpdsfwagvdkvvadltpqnqallnardel
qaqidkwhrrrviepidmdayrqflteigyllpepddftittsgvdaeitttagpqlvvp
vlnarfalnaanarwgslydalygtdvipetdgaekgptynkvrgdkviayarkflddsv
plssgsfgdatgftvqdgqlvvalpdkstglanpgqfagytgaaesptsvllinhglhie
ilidpesqvgttdragvkdvilesaittimdfedsvaavdaadkvlgyrnwlglnkgdla
aavdkdgtaflrvlnrdrnytapgggqftlpgrslmfvrnvghlmtndaivdtdgsevfe
gimdalftgliaihglkasdvngplinsrtgsiyivkpkmhgpaevaftcelfsrvedvl
glpqntmkigimdeerrttvnlkacikaaadrvvfintgfldrtgdeihtsmeagpmvrk
gtmksqpwilayedhnvdaglaagfsgraqvgkgmwtmtelmadmvetkiaqpragasta
wvpsptaatlhalhyhqvdvaavqqglagkrratieqlltiplakelawapdeireevdn
ncqsilgyvvrwvdqgvgaskvpdihdvalmedratlrissqllanwlrhgvitsadvra
slermaplvdrqnagdvayrpmapnfddsiaflaaqelilsgaqqpngytepilhrrrre
fkaraaekpapsdragddaar

    Sequence, based on observed residues (ATOM records): (download) 
    >5t8gA (A:)
tdrvsvgnlriarvlydfvnnealpgtdidpdsfwagvdkvvadltpqnqallnardelq
aqidkwhrrrviepidmdayrqflteigyllpepddftittsgvdaeitttagpqlvvpv
lnarfalnaanarwgslydalygtdvipetdgaekgptynkvrgdkviayarkflddsvp
lssgsfgdatgftvqdgqlvvalpdkstglanpgqfagytgaaesptsvllinhglhiei
lidpesqvgttdragvkdvilesaittimdfedsvaavdaadkvlgyrnwlglnkgdlaa
rvlnrdrnytapgggqftlpgrslmfvrnvghlmtndaivdtdgsevfegimdalftgli
aihglkasdgplinsrtgsiyivkpkmhgpaevaftcelfsrvedvlglpqntmkigimd
eerrttvnlkacikaaadrvvfintgfldrtgdeihtsmeagpmvrkgtmksqpwilaye
dhnvdaglaagfsgraqvgkgmwtmtelmadmvetkiaqpragastawvpsptaatlhal
hyhqvdvaavqqglagkrratieqlltiplakelawapdeireevdnncqsilgyvvrwv
dqgvgaskvpdihdvalmedratlrissqllanwlrhgvitsadvraslermaplvdrqn
agdvayrpmapnfddsiaflaaqelilsgaqqpngytepilhrrrrefkaraae