PDB entry 5t3q

View 5t3q on RCSB PDB site
Description: Crystal structure of the c-Met kinase domain in complex with a pyrazolone inhibitor
Class: transferase/transferase inhibitor
Keywords: phosphotransferase, cancer, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2016-08-26, released 2016-09-21
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-09-21, with a file datestamp of 2016-09-16.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hepatocyte growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: MET
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581 (Start-302)
      • expression tag (303)
    Domains in SCOPe 2.06: d5t3qa1, d5t3qa2
  • Heterogens: 75H, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5t3qA (A:)
qntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihc
avkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrn
firnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglar
dmydkeyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdv
ntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfige
hyvhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5t3qA (A:)
tvhidlsalnpelvqavqhvvigpsslivhfnevighfgcvyhgtlldndgkkihcavks
lnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirn
ethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadlpvkwmale
slqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdply
evmlkcwhpkaemrpsfselvsrisaifstfigehyvh