PDB entry 5sys
View 5sys on RCSB PDB site
Description: c-Src V281C bound to N-[3-({6-[(1E)-2-cyano-3-(methylamino)-3-oxoprop-1-en-1-yl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide inhibitor
Class: transferase/transferase inhibitor
Keywords: DFG-out, covalently-linked inihibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2016-08-11, released
2017-08-16
The last revision prior to the SCOPe 2.06 freeze date was dated
2017-08-16, with a file datestamp of
2017-08-11.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Gallus gallus [TaxId:9031]
Gene: SRC
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5sysa_ - Chain 'B':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Gallus gallus [TaxId:9031]
Gene: SRC
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5sysb_ - Heterogens: 72F, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5sysA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgecwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>5sysA (A:)
daweipreslrlevklgqgcfgecwmgtwngttrvaiktlkpgtmspeaflqeaqvmkkl
rheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvadfgpikwtapeaalygrftiksdvwsfgilltel
ttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqaf
ledyftstepqyqpgenl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5sysB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgecwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>5sysB (B:)
daweipreslrlevklgqgcfgecwmgtwngttrvaiktlkpgtmspeaflqeaqvmkkl
rheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvadfgpikwtapeaalygrftiksdvwsfgilltel
ttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqaf
ledyftstepqyqpgenl