PDB entry 5sx5

View 5sx5 on RCSB PDB site
Description: Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R.
Class: transferase/immune system
Keywords: Cetuximab, panitumumab, EGFR, Vectibix, Erbitux, TRANSFERASE-IMMUNE SYSTEM complex
Deposited on 2016-08-09, released 2016-10-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-10-05, with a file datestamp of 2016-09-30.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Panitumumab Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5SX5 (0-End)
    Domains in SCOPe 2.08: d5sx5h1, d5sx5h2
  • Chain 'J':
    Compound: Panitumumab Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5SX5 (0-End)
    Domains in SCOPe 2.08: d5sx5j1, d5sx5j2
  • Chain 'K':
    Compound: Panitumumab Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5SX5 (0-End)
    Domains in SCOPe 2.08: d5sx5k1, d5sx5k2
  • Chain 'L':
    Compound: Panitumumab Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5SX5 (0-End)
    Domains in SCOPe 2.08: d5sx5l1, d5sx5l2
  • Chain 'M':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (4-194)
      • expression tag (3)
      • conflict (21)
      • conflict (113)
      • engineered mutation (161)
      • expression tag (195-196)
    Domains in SCOPe 2.08: d5sx5m1, d5sx5m2, d5sx5m3, d5sx5m4
  • Chain 'N':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (4-194)
      • expression tag (3)
      • conflict (21)
      • conflict (113)
      • engineered mutation (161)
    Domains in SCOPe 2.08: d5sx5n1, d5sx5n2, d5sx5n3
  • Heterogens: SO4, GOL, EDO, 1PE, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5sx5H (H:)
qvqlqesgpglvkpsetlsltctvsggsvssgdyywtwirqspgkglewighiyysgntn
ynpslksrltisidtsktqfslklssvtaadtaiyycvrdrvtgafdiwgqgtmvtvssa
stkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssnfgtqtytcnvdhkpsntkvdktverkc

    Sequence, based on observed residues (ATOM records): (download) 
    >5sx5H (H:)
qvqlqesgpglvkpsetlsltctvsggsvssgdyywtwirqspgkglewighiyysgntn
ynpslksrltisidtsktqfslklssvtaadtaiyycvrdrvtgafdiwgqgtmvtvssa
stkgpsvfplapcstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss
vvtvpsqtytcnvdhkpsntkvdktve

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >5sx5J (J:)
qvqlqesgpglvkpsetlsltctvsggsvssgdyywtwirqspgkglewighiyysgntn
ynpslksrltisidtsktqfslklssvtaadtaiyycvrdrvtgafdiwgqgtmvtvssa
stkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssnfgtqtytcnvdhkpsntkvdktverkc

    Sequence, based on observed residues (ATOM records): (download) 
    >5sx5J (J:)
qvqlqesgpglvkpsetlsltctvsggsvssgdyywtwirqspgkglewighiyysgntn
ynpslksrltisidtsktqfslklssvtaadtaiyycvrdrvtgafdiwgqgtmvtvssa
stkgpsvfplapcsstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls
svvtvpqtytcnvdhkpsntkvdktve

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >5sx5K (K:)
diqmtqspsslsasvgdrvtitcqasqdisnylnwyqqkpgkapklliydasnletgvps
rfsgsgsgtdftftisslqpediatyfcqhfdhlplafgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >5sx5K (K:)
diqmtqspsslsasvgdrvtitcqasqdisnylnwyqqkpgkapklliydasnletgvps
rfsgsgsgtdftftisslqpediatyfcqhfdhlplafgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5sx5L (L:)
diqmtqspsslsasvgdrvtitcqasqdisnylnwyqqkpgkapklliydasnletgvps
rfsgsgsgtdftftisslqpediatyfcqhfdhlplafgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >5sx5L (L:)
diqmtqspsslsasvgdrvtitcqasqdisnylnwyqqkpgkapklliydasnletgvps
rfsgsgsgtdftftisslqpediatyfcqhfdhlplafgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >5sx5M (M:)
leekkvcngigigefkdslsidatnikhfknctsisgdlhilpvafrgdsfthtppldpq
eldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslditslgl
rslkeisdgdviisgnknlcyantinwkklfgtsgqktkiirnrgensckatgqvchalc
spegcwgpeprdcvshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5sx5M (M:)
kkvcngigigefkdslsidatnikhfknctsisgdlhilpvafrgdsfthtppldpqeld
ilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslditslglrsl
keisdgdviisgnknlcyantinwkklfgtsgqktkiirnrgensckatgqvchalcspe
gcwgpeprdcvshh

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >5sx5N (N:)
leekkvcngigigefkdslsidatnikhfknctsisgdlhilpvafrgdsfthtppldpq
eldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslditslgl
rslkeisdgdviisgnknlcyantinwkklfgtsgqktkiirnrgensckatgqvchalc
spegcwgpeprdcvshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5sx5N (N:)
kkvcngigigefkdslsidatnikhfknctsisgdlhilpvafrgdsfthtppldpqeld
ilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslditslglrsl
keisdgdviisgnknlcyantinwkklfgtsgqktkiirnrgensckatgqvchalcspe
gcwgpeprdcvs