PDB entry 5sun

View 5sun on RCSB PDB site
Description: IDH1 R132H in complex with IDH146
Class: oxidoreductase
Keywords: inhibitor, isocitrate dehydrogenase, NADPH, OXIDOREDUCTASE
Deposited on 2016-08-03, released 2017-02-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-03-22, with a file datestamp of 2017-03-17.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874
      • engineered mutation (134)
    Domains in SCOPe 2.07: d5suna_
  • Chain 'B':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874
      • engineered mutation (134)
    Domains in SCOPe 2.07: d5sunb_
  • Heterogens: NDP, 70Q, SO4, EDO, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5sunA (A:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >5sunA (A:)
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighatdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdksie
dfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyehrl
iddmvaqamkseggfiwacknslgmmtsvlvcpdgktveaeaahgtvtrhyrmyqkgqet
stnpiasifawtrglahrakldnnkelaffanaleevsietieagfmtkdlaacikglpn
vqrsdylntfefmdklgenlkiklaqak

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5sunB (B:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >5sunB (B:)
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighharatdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdk
siedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwye
hrliddmvaqamkseggfiwacknslgmmtsvlvcpdgktveaeaahgtvtrhyrmyqkg
qetstnpiasifawtrglahrakldnnkelaffanaleevsietieagfmtkdlaacikg
lpnvqrsdylntfefmdklgenlkiklaqa