PDB entry 5sct

View 5sct on RCSB PDB site
Description: Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-783
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Mycobacterium tuberculosis, DHFR, NADP, Folate, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID
Deposited on 2021-12-20, released 2022-02-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-03-02, with a file datestamp of 2022-02-25.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Gene: folA, dfrA, Rv2763c, MTV002.28c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNX1 (20-178)
      • initiating methionine (0)
      • expression tag (1-19)
    Domains in SCOPe 2.08: d5scta1, d5scta2
  • Heterogens: H03, NAP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5sctA (A:)

    Sequence, based on observed residues (ATOM records): (download)
    >5sctA (A:)