PDB entry 5sax

View 5sax on RCSB PDB site
Description: DDR1, 2-[3-(2-pyridin-3-ylethynyl)phenyl]-N-[3-(trifluoromethyl)phenyl]acetamide, 1.902A, second P212121 form, Rfree=25.4%, second form
Class: transferase/transferase inhibitor
Keywords: RTK, RECEPTOR TYROSINE KINASE, COLLAGEN, DISCOIDIN DOMAIN;, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2021-06-22, released 2022-06-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-06-29, with a file datestamp of 2022-06-24.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: epithelial discoidin domain-containing receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08345 (0-314)
      • expression tag (315-320)
    Domains in SCOPe 2.08: d5saxa_
  • Heterogens: 1IM, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5saxA (A:)
pgavgdgpprvdfprsrlrfkeklgegqfgevhlcevdspqdlvsldfplnvrkghpllv
avkilrpdatknarndflkevkimsrlkdpniirllgvcvqddplcmitdymengdlnqf
lsahqledkaaegapgdptisypmllhvaaqiasgmrylatlnfvhrdlatrnclvgenf
tikiadfgmsrnlyagdyyrvqgravlpirwmawecilmgkfttasdvwafgvtlwevlm
lcraqpfgqltdeqvienageffrdqgrqvylsrppacpqglyelmlrcwsreseqrppf
sqlhrflaedalntvhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5saxA (A:)
prvdfprsrlrfkeklgegqfgevhlcevdspqdlvsldfpghpllvavkilrpdatkna
rndflkevkimsrlkdpniirllgvcvqddplcmitdymengdlnqflsahqledkaaeg
apgdptisypmllhvaaqiasgmrylatlnfvhrdlatrnclvgenftikiadfgmsrnl
yagdyyrvqgravlpirwmawecilmgkfttasdvwafgvtlwevlmlcraqpfgqltde
qvienageffrdqgrqvylsrppacpqglyelmlrcwsreseqrppfsqlhrflaedaln
tv