PDB entry 5qik

View 5qik on RCSB PDB site
Description: TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide
Class: transferase/transferase inhibitor
Keywords: alk5, sb431542, kinase domain, transferase-transferase inhibitor complex, transferase
Deposited on 2018-08-05, released 2018-10-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-10-31, with a file datestamp of 2018-10-26.
Experiment type: XRAY
Resolution: 1.58 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR1, ALK5, SKR4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36897 (3-End)
      • expression tag (0-2)
      • engineered mutation (7)
    Domains in SCOPe 2.07: d5qika1, d5qika2
  • Heterogens: J2M, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5qikA (A:)
    ghmtiardivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrh
    enilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahl
    hmeivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtk
    rymapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdp
    sveemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqls
    qqegikm
    

    Sequence, based on observed residues (ATOM records): (download)
    >5qikA (A:)
    ghmtiardivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrh
    enilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahl
    hmeivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtk
    rymapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdp
    sveemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqls
    qqe