PDB entry 5qij
View 5qij on RCSB PDB site
Description: crystal structure of murine 11b- hydroxysteroiddehydrogenase complexed with 2-(3-(1-(4- chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-8- yl)propan-2-ol
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: 11B-HSD1, SDR, DEHYDROGENASE, HYDROXYSTEROID, INHIBITOR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on
2018-07-03, released
2018-12-19
The last revision prior to the SCOPe 2.08 freeze date was dated
2021-05-12, with a file datestamp of
2021-05-07.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Mus musculus [TaxId:10090]
Gene: Hsd11b1, Hsd11
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5qija_ - Chain 'B':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Mus musculus [TaxId:10090]
Gene: Hsd11b1, Hsd11
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5qijb_ - Heterogens: NAP, HJG, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5qijA (A:)
mhhhhhhneefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvs
rclelgaasahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsv
rrvmevnflsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffst
irtelyitkvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksev
yydkspltpillgnpgrkimeffslryynkdmfvsn
Sequence, based on observed residues (ATOM records): (download)
>5qijA (A:)
eefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaa
sahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnf
lsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffstirtelyit
kvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydksplt
pillgnpgrkimeffslryynkdmf
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5qijB (B:)
mhhhhhhneefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvs
rclelgaasahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsv
rrvmevnflsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffst
irtelyitkvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksev
yydkspltpillgnpgrkimeffslryynkdmfvsn
Sequence, based on observed residues (ATOM records): (download)
>5qijB (B:)
eefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaa
sahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnf
lsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffstirtelyit
kvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydksplt
pillgnpgrkimeffslryynkdmf