PDB entry 5pgz
View 5pgz on RCSB PDB site
Description: crystal structure of murine 11beta- hydroxysteroiddehydrogenase complexed with 2-[(5r,7s)-6-hydroxy-2-phenyladamantan-2-yl]-1-(3-hydroxyazetidin-1-yl)ethan-1-one (bms-816336)
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: 11B-HSD1, SDR, DEHYDROGENASE, HYDROXYSTEROID, INHIBITOR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBI complex, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on
2017-02-06, released
2017-11-01
The last revision prior to the SCOPe 2.06 freeze date was dated
2017-11-01, with a file datestamp of
2017-10-27.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Mus musculus [TaxId:10090]
Gene: Hsd11b1, Hsd11
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5pgza_ - Chain 'B':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Mus musculus [TaxId:10090]
Gene: Hsd11b1, Hsd11
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5pgzb_ - Heterogens: NAP, 8KG, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5pgzA (A:)
mhhhhhhneefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvs
rclelgaasahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsv
rrvmevnflsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffst
irtelyitkvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksev
yydkspltpillgnpgrkimeffslryynkdmfvsn
Sequence, based on observed residues (ATOM records): (download)
>5pgzA (A:)
eefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaa
sahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnf
lsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffstirtelyit
kvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydksplt
pillgnpgrkimeffslryynkdmf
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5pgzB (B:)
mhhhhhhneefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvs
rclelgaasahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsv
rrvmevnflsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffst
irtelyitkvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksev
yydkspltpillgnpgrkimeffslryynkdmfvsn
Sequence, based on observed residues (ATOM records): (download)
>5pgzB (B:)
eefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaa
sahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnf
lsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffstirtelyit
kvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydksplt
pillgnpgrkimeffslryynkdmf