PDB entry 5oy6

View 5oy6 on RCSB PDB site
Description: Crystal structure of the ACVR1 (ALK2) kinase in complex with cyclical inhibitor OD36.
Class: signaling protein
Keywords: Kinase, ALK2, Receptor, BMP, Structural Genomics, Structural Genomics Consortium, SGC, SIGNALING PROTEIN
Deposited on 2017-09-07, released 2017-09-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-12-13, with a file datestamp of 2017-12-08.
Experiment type: XRAY
Resolution: 2.56 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771
      • engineered mutation (8)
    Domains in SCOPe 2.07: d5oy6a_
  • Chain 'B':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771
      • engineered mutation (8)
    Domains in SCOPe 2.07: d5oy6b_
  • Chain 'C':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771
      • engineered mutation (8)
    Domains in SCOPe 2.07: d5oy6c_
  • Chain 'D':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771 (Start-300)
      • engineered mutation (8)
    Domains in SCOPe 2.07: d5oy6d_
  • Heterogens: B4E, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5oy6A (A:)
smqrtvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >5oy6A (A:)
varditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenil
gfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhiei
fgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqldvgnnprvgtkrymapevl
detiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmrkv
vcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5oy6B (B:)
smqrtvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >5oy6B (B:)
tvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrheni
lgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhie
ifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqldvgnnprvgtkrymapev
ldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmrk
vvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5oy6C (C:)
smqrtvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >5oy6C (C:)
varditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenil
gfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhiei
fgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqldvgnnprvgtkrymapevl
detiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmrkv
vcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5oy6D (D:)
smqrtvarditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >5oy6D (D:)
varditllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenil
gfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhiei
fgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqldvgnnprvgtkrymapevl
detiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmrkv
vcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltkid