PDB entry 5ove

View 5ove on RCSB PDB site
Description: Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 1
Class: signaling protein
Keywords: Guanine exchange factor, GEF, inhibitor, SOS1, SIGNALING PROTEIN
Deposited on 2017-08-28, released 2019-02-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-06, with a file datestamp of 2019-03-01.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07889 (0-End)
      • engineered mutation (0-3)
    Domains in SCOPe 2.08: d5ovea_
  • Heterogens: AXE, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5oveA (A:)
gamaeeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmya
dpnfvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrk
eyiqpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqr
kkiardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyrav
qpselvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieil
qvfqelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylakl
rsinppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpy
clrvesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspg
vrpsnprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >5oveA (A:)
gamaeeqmrlpsadvyrfaepdseeniifeegipiikagtviklierltyhmyadpnfvr
tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
tfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtke
dkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvl
evvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgi
yltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffe
nlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn