PDB entry 5ovd

View 5ovd on RCSB PDB site
Description: Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in new crystal form
Class: signaling protein
Keywords: Guanine exchange factor, GEF, inhibitor, SOS1, SIGNALING PROTEIN
Deposited on 2017-08-28, released 2019-02-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-02-06, with a file datestamp of 2019-02-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07889 (0-End)
      • engineered mutation (0-3)
    Domains in SCOPe 2.07: d5ovda_
  • Heterogens: EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5ovdA (A:)
    gamaeeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmya
    dpnfvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrk
    eyiqpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqr
    kkiardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyrav
    qpselvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieil
    qvfqelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylakl
    rsinppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpy
    clrvesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspg
    vrpsnprpgt
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ovdA (A:)
    gamaeeqmrlpsadvyrfaepdseeniifeegipiikagtviklierltyhmyadpnfvr
    tflttyrsfckpqellsliierfeipepepteadriaplsaelkrfrkeyiqpvqlrvln
    vcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiartfqsspp
    tvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeinsp
    nllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsamn
    sspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnilk
    teegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgn
    smekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn