PDB entry 5oq5
View 5oq5 on RCSB PDB site
Description: Structure of CHK1 8-pt. mutant complex with aminopyrimido-benzodiazepinone LRRK2 inhibitor
Class: transferase
Keywords: Parkinson's disease, Leucine-rich repeat kinase 2, LRRK2, Checkpoint kinase 1, CHK1, mutant, surrogate, kinase inhibitor, TRANSFERASE
Deposited on
2017-08-10, released
2017-10-25
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-11-22, with a file datestamp of
2017-11-17.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.52
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Serine/threonine-protein kinase Chk1
Species: Homo sapiens [TaxId:9606]
Gene: CHEK1, CHK1
Database cross-references and differences (RAF-indexed):
- Uniprot O14757
- engineered mutation (58)
- engineered mutation (67)
- engineered mutation (83)
- engineered mutation (85-86)
- engineered mutation (90)
- engineered mutation (133)
- engineered mutation (146)
Domains in SCOPe 2.07: d5oq5a_ - Heterogens: 4K4, MES, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5oq5A (A:)
mavpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicilk
mlnhenvikfyghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvy
lhgigithrdikphnlllderdnlkiadfglatvfrynnrerllnkmcgtlpyvapellk
rrefhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsapla
llhkilvenpsaritipdikkdrwynkplkkgakrprvtsggvsespsghhhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>5oq5A (A:)
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkrcpenikkeicilkmlnhe
nvikfyghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvylhgig
ithrdikphnlllderdnlkiadfglatvfrynnrerllnkmcgtlpyvapellkrrefh
aepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhki
lvenpsaritipdikkdrwynkplk