PDB entry 5ohj

View 5ohj on RCSB PDB site
Description: Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor.
Class: hydrolase
Keywords: human phosphodiesterase 4B, hydrolase, pyrrolidinyl inhibitor, PDE4B
Deposited on 2017-07-17, released 2017-12-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-12-13, with a file datestamp of 2017-12-08.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4B, DPDE4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ohja_
  • Chain 'B':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4B, DPDE4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ohjb_
  • Heterogens: ZN, MG, 9VE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ohjA (A:)
msvsemasnkfkrmlnrelthlsemsrsgnqvseyisntfldkqndveipkvtaeeapqp
mtqisgvkklmhssslnntsisrfgvntenedhlakeledlnkwglnifnvagyshnrpl
tcimyaifqerdllktfrissdtfitymmtledhyhsdvayhnslhaadvaqsthvllst
paldavftdleilaaifaaaihdvdhpgvsnqflintnselalmyndesvlenhhlavgf
kllqeehcdifmnltkkqrqtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvl
lldnytdriqvlrnmvhcadlsnptkslelyrqwtdrimeeffqqgdkerergmeispmc
dkhtasveksqvgfidyivhplwetwadlvqpdaqdildtlednrnwyqsmipqshhhhh
h

    Sequence, based on observed residues (ATOM records): (download) 
    >5ohjA (A:)
tsisrfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfr
issdtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifa
aaihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkq
rqtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhc
adlsnptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyi
vhplwetwadlvqpdaqdildtlednrnwyqsmipq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ohjB (B:)
msvsemasnkfkrmlnrelthlsemsrsgnqvseyisntfldkqndveipkvtaeeapqp
mtqisgvkklmhssslnntsisrfgvntenedhlakeledlnkwglnifnvagyshnrpl
tcimyaifqerdllktfrissdtfitymmtledhyhsdvayhnslhaadvaqsthvllst
paldavftdleilaaifaaaihdvdhpgvsnqflintnselalmyndesvlenhhlavgf
kllqeehcdifmnltkkqrqtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvl
lldnytdriqvlrnmvhcadlsnptkslelyrqwtdrimeeffqqgdkerergmeispmc
dkhtasveksqvgfidyivhplwetwadlvqpdaqdildtlednrnwyqsmipqshhhhh
h

    Sequence, based on observed residues (ATOM records): (download) 
    >5ohjB (B:)
sisrfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfri
ssdtfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaa
aihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqr
qtlrkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhca
dlsnptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyiv
hplwetwadlvqpdaqdildtlednrnwyqsmipq