PDB entry 5oca

View 5oca on RCSB PDB site
Description: PCSK9:Fab Complex with Dextran Sulfate
Class: hydrolase
Keywords: hydrolase, protein fab complex, autocatalytic cleavage, cholesterol metabolism, disease mutation, disulfide bond, glycoprotein, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, hydrolase-immune system complex
Deposited on 2017-06-30, released 2017-09-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBP7 (0-End)
      • conflict (321)
      • conflict (380)
      • conflict (467)
    Domains in SCOPe 2.08: d5ocab1, d5ocab2
  • Chain 'H':
    Compound: Fab from LDLR competitive antibody: Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5OCA (0-End)
    Domains in SCOPe 2.08: d5ocah_
  • Chain 'L':
    Compound: Fab from LDLR competitive antibody: Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5OCA (0-End)
    Domains in SCOPe 2.08: d5ocal1, d5ocal2
  • Heterogens: TWA, TWD, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ocaB (B:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthgag
wqlfcrtvwsahsgptrmataiarcapdeellscssfsrsgkrrgermeaqggklvcrah
nafggegvyaiarccllpqaacsvhtappaeasmgtrvhchqqghvltgcsshwevedlg
thkppvlrprgqpnqcvghreasihascchapgleckvkehgipapqgqvtvaceegwtl
tgcsalpgtshvlgayavdntcvvrsrdvsttgstseeavtavaiccrsrhlaqasqelq

    Sequence, based on observed residues (ATOM records): (download) 
    >5ocaB (B:)
sipwnleritppryradlvevylldtsiqsdhreiegrvmvtdfenvpeedgtrfhrqas
kcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvg
plvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatna
qdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammls
aepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthqlfcrtvwsahs
gptrmataiarcapdeellscssfsrsgkrrgermeaqggklvcrahnafggegvyaiar
ccllpqaacsvhtappaeasmgtrvhchqqghvltgcsshwevedlgtpnqcvghreasi
hascchapgleckvkehgipapqgqvtvaceegwtltgcsalpgtshvlgayavdntcvv
rsravtavaiccrsr

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5ocaH (H:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgkglewvssisssssyisy
adsvkgrftisrdnaknslylqmnslraedtavyfcardydfwsayydafdvwgqgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscaadevdhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5ocaH (H:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgkglewvssisssssyisy
adsvkgrftisrdnaknslylqmnslraedtavyfcardydfwsayydafdvwgqgtmvt
vssastkgpsvfplapsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5ocaL (L:)
esvltqppsvsgapgqrvtisctgsssnigagydvhwyqqlpgtapkllisgnsnrpsgv
pdrfsgsksgtsaslaitglqaedeadyycqsydsslsgsvfgggtkltvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >5ocaL (L:)
esvltqppsvsgapgqrvtisctgsssnigagydvhwyqqlpgtapkllisgnsnrpsgv
pdrfsgsksgtsaslaitglqaedeadyycqsydsslsgsvfgggtkltvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvapt